The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery

被引：65

作者：

Gintant, Gary ^{[1
]}

Fermini, Bernard ^{[2
]}

Stockbridge, Norman ^{[3
]}

Strauss, David ^{[4
]}

机构：

[1] AbbVie, Integrated Sci & Technol, Dept Integrat Pharmacol ZR13, Bldg AP-9A LL,1 North Waukegan Rd, N Chicago, IL 60064 USA

[2] Coyne Sci, 58 Edgewood Ave NE, Atlanta, GA 30303 USA

[3] US FDA, Ctr Drug Evaluat & Res, Div Cardiovasc & Renal Prod, Silver Spring, MD 20993 USA

[4] US FDA, Ctr Drug Evaluat & Res, Div Appl Regulatory Sci, Silver Spring, MD 20993 USA

来源：

CELL STEM CELL | 2017年 / 21卷 / 01期

关键词：

CARDIOTOXICITY;

D O I：

10.1016/j.stem.2017.06.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Nonclinical studies of drug effects with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide new possibilities for evaluating drug safety and efficacy. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm provides lessons from the cardiac field that also apply to drug studies with other stem cell-based assays.

引用

页码：14 / 17

页数：4

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