Synthesis, crystal structure, and antitumour activities of cobalt(II) complex based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine

被引：9
|
作者：
Li, G. B. [1 ]
Wang, S. X. [2 ]
Su, W. Y. [1 ]
Pan, R. K. [1 ]
Liu, K. D. [1 ]
Liu, S. G. [1 ]
机构：
[1] Lingnan Normal Univ, Sch Chem & Chem Engn, Zhanjiang 524048, Peoples R China
[2] Shenzhen Univ, Sch Med, Inst Mol Med, Shenzhen 518060, Peoples R China
来源：
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY | 2014年 / 40卷 / 10期
基金：
中国国家自然科学基金;
关键词：
DNA MINOR-GROOVE; APOPTOSIS; STRESS;
D O I：
10.1134/S1070328414100054
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new cationic complex, [Co(Bpbp)(2)](ClO4)(2) center dot DMF center dot H2O, was synthesized by treatment Co(ClO4)(2) center dot 6H(2)O with 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine (Bpbp) in DMF solvent at room temperature. Its structure was characterized by element analysis, IR, and X-ray single crystal structure analyses (CIF file CCDC no. 970498). For complex, crystal system, triclinic, space group, , a = 11.585(13), b = 13.939(16), c = 19.236(2) , alpha = 97.938(2)A degrees, beta = 102.814(2)A degrees, gamma = 90.556(2)A degrees, V = 2861.1(6) I-3, Z = 2. The Co2+ ion octahedral geometry is coordinated by six nitrogen atoms from two ligand (Bpbp). The antiproliferative activities of the complex were screened by MTT assay against HepG2, Huh7, Eca109 and Eca9706 cancer cell. The complex exhibits inhibition on Eca9706 and Eca109 cancer cell but no HepG2 and Huh7 cancer cell.
引用
收藏
页码：764 / 767
页数：4
相关论文
共 50 条
  • [21] Crystal structure and spin crossover studies on bis(2,6-bis(benzimidazol-2-yl) pyridine) iron(II) perchlorate
    Boca, R
    Baran, P
    Dlhan, L
    Fuess, H
    Haase, W
    Renz, F
    Linert, W
    Svoboda, I
    Werner, R
    INORGANICA CHIMICA ACTA, 1997, 260 (02) : 129 - 136
  • [22] Structure and photosynthetic mimicking of bis(2,6-bis(benzimidazol-2-yl)pyridine)manganese(II)
    Shi, W
    Li, W
    Shen, PP
    Xu, YK
    Wang, HM
    Shi, M
    Liu, Y
    CHINESE JOURNAL OF CHEMISTRY, 2003, 21 (06) : 659 - 664
  • [23] The copper(II) complexes di-μ-bromo-bis{[2,6-bis(pyrazol-1-yl)pyridine]perchloratocopper(II)} and [2,6-bis(pyrazol-1-yl)pyridine]dibromocopper(II)
    Chakrabarty, S
    Poddar, RK
    Poulsen, RD
    Thompson, AL
    Howard, JAK
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2004, 60 : M628 - M630
  • [24] Zinc(II) and Cobalt(II) Complexes Derived from 4-Benzyloxy-2,6-bis(1-methyl-2-benzimidazolyl)pyridine: Synthesis, Crystal Structures, Spectroscopic Properties and Antitumour Activities
    Pan, Rong-Kai
    Song, Jiang-Li
    Su, Wen-Yi
    Liu, Sheng-Gui
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2020, 50 (03) : 241 - 248
  • [25] Zinc(II) and Cobalt(II) Complexes Derived from 4-Benzyloxy-2,6-bis(1-methyl-2-benzimidazolyl)pyridine: Synthesis, Crystal Structures, Spectroscopic Properties and Antitumour Activities
    Rong-Kai Pan
    Jiang-Li Song
    Wen-Yi Su
    Sheng-Gui Liu
    Journal of Chemical Crystallography, 2020, 50 : 241 - 248
  • [26] THE SYNTHESIS AND CRYSTAL-STRUCTURE OF A CERIUM(III) COMPLEX OF 2,6-BIS[2-FORMYLPHENOXYMETHYL]PYRIDINE
    BAILEY, NA
    DEBARBARIN, COR
    FENTON, DE
    HO, YS
    HUMBER, GJ
    INORGANICA CHIMICA ACTA, 1995, 232 (1-2) : 227 - 230
  • [27] Synthesis, crystal structure and electrochemical behaviour of [2,6-bis(3,5-dimethylpyrazolyl)pyridine](dithiocyanato)cobalt(II)
    Arici, C
    Ülkü, D
    Kurtaran, R
    Emregül, KC
    Atakol, O
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 2003, 218 (07): : 497 - 500
  • [28] Microwave synthesis, characterization and DNA-binding properties of a new cobalt(II) complex with 2,6-bis(benzimidazol-2-yl)pyridine
    Tan, NY
    Xiao, XM
    Li, ZL
    Matsumura-Inoue, T
    CHINESE CHEMICAL LETTERS, 2004, 15 (06) : 687 - 690
  • [29] CRYSTAL AND MOLECULAR-STRUCTURE OF THE SOLVATE OF BIS(2,6-BIS(1'-METHYLBENZIMIDAZOL-2'-YL)PYRIDINE)COBALT(II) DIHEXAFLUOROPHOSPHATE WITH 4-METHYL-1,3-DIOXOLAN-2-ON
    SHKLOVER, V
    EREMENKO, IL
    BERKE, H
    NESPER, R
    ZAKEERUDDIN, SM
    NAZEERUDDIN, MK
    GRATZEL, M
    INORGANICA CHIMICA ACTA, 1994, 219 (1-2) : 11 - 21
  • [30] Spin State of the Cobalt(II) Complex with N,N'-Disubstituted 2,6-Bis(pyrazol-3-yl)pyridine
    E. A. Khakina
    G. L. Denisov
    I. A. Nikovskii
    A. V. Polezhaev
    Yu. V. Nelyubina
    Russian Journal of Coordination Chemistry, 2022, 48 : 344 - 352
12345