Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance

被引：25
|
作者：
Shehzad, Adeeb [1 ]
Ravinayagam, Vijaya [2 ,3 ]
AlRumaih, Hamad [4 ]
Aljafary, Meneerah [5 ]
AlMuhazay, Dana [6 ]
Almofty, Sara [6 ]
Al-Rashid, Noor A. [1 ]
Al-Suhaimi, Ebtesam [5 ,6 ]
机构：
[1] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, Dammam, Saudi Arabia
[2] Sci Res, Dammam, Saudi Arabia
[3] Imam Abdulrahman Bin Faisal Univ, Dammam, Saudi Arabia
[4] Imam Abdulrahman Bin Faisal Univ, Coll Dent, Dammam, Saudi Arabia
[5] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Biol, Dammam, Saudi Arabia
[6] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Stem Cell Res Dept, Dammam, Saudi Arabia
来源：
CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 34期
关键词：
Spheroid; 3D cell culture; drug resistance; drug discovery; cancer therapy; 2D monolayer; IN-VITRO; MULTICELLULAR SPHEROIDS; STROMAL CELLS; CANCER; CURCUMIN; MODEL; DISCOVERY; ENRICHMENT; GROWTH; PHARMACOKINETICS;
D O I：
10.2174/1381612825666191014163923
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anti-cancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems.
引用
收藏
页码：3599 / 3607
页数：9
相关论文
共 50 条
  • [31] Quantifying stroma-tumor cell interactions in three-dimensional cell culture systems.
    Cavo, Marta Maria
    Alemanno, Francesco
    Delle Cave, Donatella
    D'Amone, Eliana
    Barra, Adriano
    Lonardo, Enza
    Parasido, Erika
    Albanese, Chris
    del Mercato, Loretta Laureana
    CANCER RESEARCH, 2020, 80 (11) : 53 - 54
  • [32] Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
    Edmondson, Rasheena
    Broglie, Jessica Jenkins
    Adcock, Audrey F.
    Yang, Liju
    ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2014, 12 (04) : 207 - 218
  • [33] Fabrication and Characterization of Three-Dimensional (3D) Core-Shell Structure Nanofibers Designed for 3D Dynamic Cell Culture
    Jin, Lin
    Xu, Qinwei
    Kuddannaya, Shreyas
    Li, Cheng
    Zhang, Yilei
    Wang, Zhenling
    ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (21) : 17718 - 17726
  • [34] Progress on three-dimensional cell culture technology and their application
    Lu X.
    Liu X.
    Zhong H.
    Zhang W.
    Yu S.
    Guan R.
    Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering, 2023, 40 (03): : 602 - 608
  • [35] The application of three-dimensional cell culture in clinical medicine
    Chen, Qiao
    Wang, Youbin
    BIOTECHNOLOGY LETTERS, 2020, 42 (11) : 2071 - 2082
  • [36] The application of three-dimensional cell culture in clinical medicine
    Qiao Chen
    Youbin Wang
    Biotechnology Letters, 2020, 42 : 2071 - 2082
  • [37] Application of nanomaterials in three-dimensional stem cell culture
    Aziz, Shiva Gholizadeh-Ghaleh
    Pashaiasl, Maryam
    Khodadadi, Khodadad
    Ocheje, Onuche
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (11) : 18550 - 18558
  • [38] Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma
    Khafaga, Asmaa F.
    Mousa, Shaker A.
    Aleya, Lotfi
    Abdel-Daim, Mohamed M.
    CANCER CELL INTERNATIONAL, 2022, 22 (01)
  • [39] Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma
    Asmaa F. Khafaga
    Shaker A. Mousa
    Lotfi Aleya
    Mohamed M. Abdel-Daim
    Cancer Cell International, 22
  • [40] Three-Dimensional Cell Culture Systems in Pediatric and Adult Brain Tumor Precision Medicine
    Riedel, Nicole C.
    de Faria, Flavia W.
    Alfert, Amelie
    Bruder, Jan M.
    Kerl, Kornelius
    CANCERS, 2022, 14 (23)
12345