Attraction vs. repulsion: The growth cone decides

被引：23
|
作者：
McFarlane, S [1 ]
机构：
[1] Univ Calgary, Genes & Dev Res Grp, Calgary, AB T2N 4N1, Canada
来源：
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE | 2000年 / 78卷 / 05期
关键词：
growth cone; axon guidance; calcium; cyclic nucleotides;
D O I：
10.1139/bcb-78-5-563
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Axons are guided through their environment in response to signals provided by extracellular cues. These cues are transduced into motile responses by the tip of the growing axon, the growth cone, and can be either repulsive or attractive in nature. Recent studies have suggested that how an axon responds to any given signal depends on the internal state of the growth cone. This review discusses these studies and their importance for understanding how nerve connections are made in the developing embryo.
引用
收藏
页码：563 / 568
页数：6
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