Dual Gold Catalysis: Synthesis of Polycyclic Compounds via C-H Insertion of Gold Vinylidenes

被引：61

作者：

Wieteck, Marcel ^{[1
]}

Tokimizu, Yusuke ^{[2
]}

Rudolph, Matthias ^{[1
]}

Rominger, Frank ^{[1
]}

Ohno, Hiroaki ^{[2
]}

Fujii, Nobutaka ^{[2
]}

Hashmi, A. Stephen K. ^{[1
,3
]}

机构：

[1] Heidelberg Univ, Organ Chem Inst, D-69120 Heidelberg, Germany

[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[3] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 49期

基金：

日本学术振兴会;

关键词：

alkynes; CH insertion; gold; vinylidene ligands; polycycles; HOMOGENEOUS CATALYSIS; ALKYNES; CYCLIZATIONS; ACTIVATION; 3-SILYLOXY-1,5-ENYNES; HYDROARYLATION; PRECATALYSTS; HETEROCYCLES; CARBOCYCLES; DERIVATIVES;

D O I：

10.1002/chem.201404987

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New and interesting polycyclic compounds have been synthesized from non-conjugated diyne systems by dual gold catalysis. A quaternary carbon center in the backbone and the accompanying Thorpe-Ingold effect enabled the unprecedented insertion of sp(3) and sp(2) CH bonds that for the first time were incorporated within the backbone of the diyne system and allowed the construction of complex polycyclic carbon scaffolds inaccessible by previous approaches in which the CH bonds for the insertion were situated at the other end of the alkyne.

引用

页码：16331 / 16336

页数：6

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