Resistant depression : potentiation strategies

被引：3

作者：

Doumy, Olivier ^{[1
]}

Bennabi, Djamila ^{[2
]}

El-Hage, Wissam ^{[3
]}

Allaili, Najib ^{[4
]}

Bation, Remy ^{[5
]}

Bellivier, Frank ^{[4
]}

Holtzmann, Jerome ^{[6
]}

Bubrovszky, Maxime ^{[7
]}

Camus, Vincent ^{[3
]}

Charpeaud, Thomas ^{[8
]}

Courvoisier, Pierre ^{[6
]}

d'Amato, Thierry ^{[5
]}

Garnier, Marion ^{[8
]}

Haesebaert, Frederic ^{[5
]}

Bougerol, Thierry ^{[6
]}

Lancon, Christophe ^{[9
]}

Moliere, Fanny ^{[10
]}

Nieto, Isabel ^{[4
]}

Richieri, Raphaelle ^{[9
]}

Saba, Ghassen ^{[11
]}

Courtet, Philippe ^{[10
]}

Vaiva, Guillaume ^{[7
]}

Leboyer, Marion ^{[11
]}

Llorca, Pierre-Michel ^{[8
]}

Aouizerate, Bruno ^{[1
]}

Haffen, Emmanuel ^{[2
]}

机构：

[1] CH Charles Perrens, Ctr Expert Depress Resistante FondaMental, Pole Psychiat Gen & Univ, F-33076 Bordeaux, France

[2] CHU Besancon, Serv Psychiat Adulte, Ctr Expert Depress Resistante FondaMental, F-25030 Besancon, France

[3] CHU Tours, Ctr Expert Depress Resistante FondaMental, Clin Psychiat Univ, F-37044 Tours 9, France

[4] Hop Fernand Widal, Serv Psychiat Adulte, Ctr Expert Depress Resistante FondaMental, F-75010 Paris, France

[5] Ctr Hosp Le Vinatier, Ctr Expert Depress Resistante FondaMental, Serv Univ Psychiat Adulte, F-69678 Bron, France

[6] CHU Grenoble, Hop Nord, Ctr Expert Depress Resistante FondaMental, Serv Psychiat Adulte, CS 10217, F-38043 Grenoble 9, France

[7] CHRU Lille, Hop Fontan 1, Serv Psychiat Adulte, Ctr Expert Depress Resistante FondaMental, F-59037 Lille, France

[8] CHU Clermont Ferrand, Ctr Expert Depress Resistante FondaMental, Serv Psychiat Adulte B, F-63003 Clermont Ferrand, France

[9] CHU La Concept, Ctr Expert Depress Resistante FondaMental, Pole Psychiat Ctr, F-13005 Marseille, France

[10] CHRU Lapeyronie, Dept Urgences & Posturgences Psychiat, Ctr Expert Depress Resistante FondaMental, F-34295 Montpellier 5, France

[11] Hop Univ Henri Mondor, Hop Chenevier, Pole Psychiat, Ctr Expert Depress Resistante FondaMental, F-94000 Creteil, France

来源：

PRESSE MEDICALE | 2016年 / 45卷 / 03期

关键词：

EXTENDED-RELEASE QUETIAPINE; PLACEBO-CONTROLLED TRIAL; SEROTONIN REUPTAKE INHIBITORS; STAR-ASTERISK-D; DOUBLE-BLIND; OLANZAPINE/FLUOXETINE COMBINATION; ARIPIPRAZOLE AUGMENTATION; REFRACTORY DEPRESSION; TRIIODOTHYRONINE AUGMENTATION; RISPERIDONE AUGMENTATION;

D O I：

10.1016/j.lpm.2016.02.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lithium is among the most classically recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with lithium requires achieving plasma levels above 0.5 mEq/L. Mood-stabilizing antiepileptic drugs such as carbamazepine, valproate derivatives or lamotrigine have not demonstrated conclusive therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Thyroid hormones are considered among the currently recommended add-on therapeutic strategy for the management of depressive patients showing unsuccessful response to standard antidepressant medications. The effectiveness of the add-on strategy with thyroid hormones requires achieving plasma concentration of TSH close to the lower limits at the normal range (0.4 mUI/L) or even below it. Second-generation antipsychotics such as aripiprazole or quetiapine have consistently demonstrated significant therapeutic effects for the management of depressive patients showing unsuccessful response to standard antidepressant medications. Second-generation antipsychotics however require the careful monitoring of both cardiovascular and metabolic adverse effects.

引用

页码：338 / 349

页数：12

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