Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

被引：75

作者：

Zhou, Chao ^{[1
,2
]}

Tsai, Tsung-Han ^{[1
,2
]}

Adler, Desmond C. ^{[1
,2
,3
]}

Lee, Hsiang-Chieh ^{[1
,2
]}

Cohen, David W. ^{[4
]}

Mondelblatt, Amy ^{[4
]}

Wang, Yihong ^{[4
]}

Connolly, James L. ^{[4
]}

Fujimoto, James G. ^{[1
,2
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] LightLab Imaging Inc, Westford, MA 01886 USA

[4] Harvard Univ, Dept Pathol, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GROWTH-FACTOR RECEPTOR; CONTRAST AGENTS; NANOPARTICLES; THERAPY; CANCER; CELLS;

D O I：

10.1364/OL.35.000700

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 mu m deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. (C) 2010 Optical Society of America

引用

页码：700 / 702

页数：3

共 50 条

[31] Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography
Zhao, Q. L.
Si, J. L.
Guo, Z. Y.
Wei, H. J.
Yang, H. Q.
Wu, G. Y.
Xie, S. S.
Li, X. Y.
Guo, X.
Zhong, H. Q.
Li, L. Q.
LASER PHYSICS LETTERS, 2011, 8 (01) : 71 - 77
[32] Transscleral optical coherence tomography - An experimental study in ex-vivo human eyes
Hoerauf, H
Winkler, J
Scholz, C
Wirbelauer, C
Gordes, RS
Koch, P
Engelhardt, R
Laqua, H
Birngruber, R
LASERS IN SURGERY AND MEDICINE, 2002, 30 (03) : 209 - 215
[33] Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography
Burkhardt, Anke
Kirsten, Lars
Bornitz, Matthias
Zahnert, Thomas
Koch, Edmund
JOURNAL OF BIOPHOTONICS, 2014, 7 (06) : 434 - 441
[34] Histopathological Correlation of Optical Coherence Tomography (OCT) Images of the Human Larynx Ex Vivo
Tadrous, P. J.
Tatla, T.
Cernat, R.
Podoleanu, A.
JOURNAL OF PATHOLOGY, 2012, 226 : S20 - S20
[35] Evaluation of optical coherence tomography for assessment of epithelialization in human ex vivo wound model
Glinos, George
Verne, Sebastian
Aldahan, Adam
Liang, Liang
Nouri, Keyvan
Tomic-Canic, Marjana
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 76 (06) : AB130 - AB130
[36] Nanoshells as an optical coherence tomography contrast agent
Barton, JK
Halas, NJ
West, JL
Drezek, RA
COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VIII, 2004, 5316 : 99 - 106
[37] Ex vivo sensing of primordial follicles in ovarian tissues by spectral-domain optical coherence tomography
Hosoda, Masaki
Oida, Daisuke
Ito, Koichiro
Takae, Seido
Suzuki, Nao
Tsukada, Kosuke
MEDICAL IMAGING 2022: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING, 2022, 12036
[38] Use of formalin-fixed tissues for ex-vivo imaging with optical coherence tomography (OCT)
Shortkroff, Sonya
Goodwin, Alicia
Giattina, Susanne
Liu, Bin
Brezinski, Mark E.
IMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES IV, 2006, 6088
[39] BINARY TISSUE CLASSIFICATION STUDIES ON RESECTED HUMAN BREAST TISSUES USING OPTICAL COHERENCE TOMOGRAPHY IMAGES
Bhattacharjee, M.
Ashok, P. C.
Rao, K. Divakar
Majumder, S. K.
Verma, Y.
Gupta, P. K.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES, 2011, 4 (01) : 59 - 66
[40] Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography
Thu-Mai Nguyen
Song, Shaozhen
Shi, Lei
Wang, Ruikang K.
O'Donnell, Matthew
Shen, Tueng T.
Huang, Zhihong
2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), 2014, : 217 - 220

← 1 2 3 4 5 →