Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

被引：75

作者：

Zhou, Chao ^{[1
,2
]}

Tsai, Tsung-Han ^{[1
,2
]}

Adler, Desmond C. ^{[1
,2
,3
]}

Lee, Hsiang-Chieh ^{[1
,2
]}

Cohen, David W. ^{[4
]}

Mondelblatt, Amy ^{[4
]}

Wang, Yihong ^{[4
]}

Connolly, James L. ^{[4
]}

Fujimoto, James G. ^{[1
,2
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] LightLab Imaging Inc, Westford, MA 01886 USA

[4] Harvard Univ, Dept Pathol, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GROWTH-FACTOR RECEPTOR; CONTRAST AGENTS; NANOPARTICLES; THERAPY; CANCER; CELLS;

D O I：

10.1364/OL.35.000700

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 mu m deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells. (C) 2010 Optical Society of America

引用

页码：700 / 702

页数：3

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