Optimization of prednisolone acetate-loaded chitosan microspheres using a 23 factorial design for preventing restenosis

被引：11

作者：

Sarisozen, Can ^{[1
]}

Arica, Betuel ^{[1
]}

Orman, Mehmet N. ^{[2
]}

Hincal, A. Atilla ^{[1
]}

Calis, Sema ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey

[2] Ege Univ, Fac Med, Dept Biostat & Med Informat, TR-35100 Bornova, Turkey

来源：

DRUG DELIVERY | 2010年 / 17卷 / 03期

关键词：

Microspheres; prednisolone acetate; chitosan; factorial design; spray-drying; DRUG-ELUTING STENTS; CONTROLLED-RELEASE; DELIVERY; ENCAPSULATION;

D O I：

10.3109/10717541003667780

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2<SU3</SU) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 +/- 6.7%) and encapsulation efficiency (45.7 +/- 0.3%), and released the drug at a constant rate in 11 days.</.

引用

页码：178 / 186

页数：9

共 50 条

[41] Development and Statistical Optimization of Solid Lipid Nanoparticles of Simvastatin by Using 23 Full-Factorial Design
Mayank Shah
Kamla Pathak
AAPS PharmSciTech, 2010, 11 : 489 - 496
[42] Development and Statistical Optimization of Solid Lipid Nanoparticles of Simvastatin by Using 23 Full-Factorial Design
Shah, Mayank
Pathak, Kamla
AAPS PHARMSCITECH, 2010, 11 (02): : 489 - 496
[43] Screening of ionically crosslinked chitosan-tripolyphosphate microspheres using Plackett-Burman factorial design for the treatment of intrapocket infections
Yadav, Sarita Kumari
Khan, Gayasuddin
Bansal, Monika
Vardhan, Harsh
Mishra, Brahmeshwar
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2017, 43 (11) : 1801 - 1816
[44] Mebeverine Hydrochloride Loaded Chitosan Microspheres as Potential Treatment Targeting Irritable Bowel Syndrome: Box-Behnken Design Optimization
Hasan, Azza Ali
Samir, Rasha Mohamed
Abu-Zaid, Samir Sayed
Abu Lila, Amr Selim
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2020, 10 (03) : 326 - 331
[45] Design, Development and Optimization of Carmustine- Loaded Freeze-Dried Nanoliposomal Formulation Using 32 Factorial Design Approach
Honmane, Sandip M.
Charde, Manoj S.
Osmani, Riyaz Ali M.
ACTA CHIMICA SLOVENICA, 2023, 70 (02) : 204 - 217
[46] Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation
Patil, Pritam
Khairnar, Gokul
Naik, Jitendra
CHEMICAL ENGINEERING RESEARCH & DESIGN, 2015, 104 : 98 - 109
[47] Formulation and optimization of lornoxicam-loaded bilosomes using 23 full factorial design for the management of osteoarthritis in rats: Modulation of MAPK/Erk1 signaling pathway
Salama, Abeer
El-Hashemy, Hadeer A. A.
Darwish, Asmaa Badawy
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 69
[48] Optimization of the preparation of nalmefene-loaded sustained-release microspheres using central composite design
Wu, Xiang-Gen
Li, Gao
Gao, Yong-Liang
CHEMICAL & PHARMACEUTICAL BULLETIN, 2006, 54 (07) : 977 - 981
[49] Optimization and Evaluation of Gastroretentive Ranitidine HCl Microspheres by Using Factorial Design with Improved Bioavailability and Mucosal Integrity in Ulcer Model
Abeer Khattab
Nashwah Zaki
AAPS PharmSciTech, 2017, 18 : 957 - 973
[50] Optimization and Evaluation of Gastroretentive Ranitidine HCl Microspheres by Using Factorial Design with Improved Bioavailability and Mucosal Integrity in Ulcer Model
Khattab, Abeer
Zaki, Nashwah
AAPS PHARMSCITECH, 2017, 18 (04): : 957 - 973

← 1 2 3 4 5 →