Microbiome: Focus on Causation and Mechanism

被引：164

作者：

Fischbach, Michael A. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, ChEM H, Stanford, CA 94305 USA

[3] Chan Zuckerberg Biohub, Stanford, CA 94305 USA

来源：

CELL | 2018年 / 174卷 / 04期

关键词：

WIDE ASSOCIATION; GUT MICROBIOTA; COMMENSAL; HOST; INDIVIDUALS; ENGRAFTMENT; RESISTANCE; MODULATE; REVEALS; STRAINS;

D O I：

10.1016/j.cell.2018.07.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by the microbiota.

引用

页码：785 / 790

页数：6

共 50 条

[1] Pathogen versus microbiome causation in the holobiont
Aja Watkins
Federica Bocchi
Biology & Philosophy, 2020, 35
[2] Pathogen versus microbiome causation in the holobiont
Watkins, Aja
Bocchi, Federica
BIOLOGY & PHILOSOPHY, 2020, 35 (01)
[3] Menopause, the gut microbiome, and weight gain: correlation or causation?
Becker, Sarah L.
Manson, JoAnn E.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2021, 28 (03): : 327 - 331
[4] The respiratory tract microbiome: moving from correlation to causation
Morton, Richard
Singanayagam, Aran
EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (05)
[5] Elite controllers microbiome: unraveling the mystery of association and causation
Bai, Xiangning
Sonnerborg, Anders
Nowak, Piotr
CURRENT OPINION IN HIV AND AIDS, 2024, 19 (05) : 261 - 267
[6] Association or Causation? Exploring the Oral Microbiome and Cancer Links
Teles, F. R. F.
Alawi, F.
Castilho, R. M.
Wang, Y.
JOURNAL OF DENTAL RESEARCH, 2020, 99 (13) : 1411 - 1424
[7] The mechanism and causation of hot waves
Watts, HM
JOURNAL OF THE FRANKLIN INSTITUTE, 1903, 153 : 285 - 293
[8] Human Gut Microbiome and Liver Diseases: From Correlation to Causation
Li, Rui
Mao, Zhengsheng
Ye, Xujun
Zuo, Tao
MICROORGANISMS, 2021, 9 (05)
[9] Role of the intestinal microbiome in health and disease: from correlation to causation
de Vos, Willem M.
de Vos, Elisabeth A. J.
NUTRITION REVIEWS, 2012, 70 : S45 - S56
[10] Focus of attention and sport spectators: Beliefs about causation
Wann, DL
Brewer, KR
Carlson, JD
PERCEPTUAL AND MOTOR SKILLS, 1998, 87 (01) : 35 - 41

← 1 2 3 4 5 →