Injectable hydrogels for cartilage and bone tissue engineering

被引：947
|
作者：
Liu, Mei [1 ]
Zeng, Xin [2 ]
Ma, Chao [1 ]
Yi, Huan [1 ]
Ali, Zeeshan [3 ,4 ]
Mou, Xianbo [1 ]
Li, Song [5 ]
Deng, Yan [1 ,5 ]
He, Nongyue [1 ,5 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Matern & Child Hlth Care Hosp, Nanjing, Jiangsu, Peoples R China
[3] Shenzhen Polytech, Sch Appl Chem & Biotechnol, Shenzhen, Peoples R China
[4] Southeast Univ, Sch Chem & Chem Engn, Nanjing, Jiangsu, Peoples R China
[5] Hunan Univ Technol, Hunan Key Lab Green Chem & Applicat Biol Nanotech, Zhuzhou, Peoples R China
来源：
BONE RESEARCH | 2017年 / 5卷
基金：
中国博士后科学基金;
关键词：
CHITOSAN-BASED HYDROGELS; MESENCHYMAL STEM-CELLS; SITU FORMING HYDROGELS; HEPARIN-BASED HYDROGEL; HYALURONIC-ACID; EXTRACELLULAR-MATRIX; ARTICULAR-CARTILAGE; CROSS-LINKING; CHONDROITIN SULFATE; CONTROLLED-RELEASE;
D O I：
10.1038/boneres.2017.14
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
引用
收藏
页数：20
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