Effect of Atorvastatin on Cellular Adhesion Molecules on Leukocytes in Patients with Normocholesterolemic Coronary Artery Disease

被引：0
|
作者：
Walter, Thomas [1 ]
Suselbeck, Tim [1 ]
Borggrefe, Martin [1 ]
Swoboda, Stefanie [3 ]
Hoffmeister, Hans Martin [2 ]
Dempfle, Carl-Erik [1 ]
机构：
[1] Univ Med Ctr Mannheim, Dept Med 1, D-68167 Mannheim, Germany
[2] Staedt Klinikum, Dept Internal Med 2, Solingen, Germany
[3] Univ Heidelberg Hosp, Dept Pharm, Heidelberg, Germany
来源：
IN VIVO | 2010年 / 24卷 / 02期
关键词：
Atorvastatin; coronary artery disease; cellular adhesion molecules; leukocytes; inflammation; SOLUBLE CD40 LIGAND; INCREASED EXPRESSION; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; INFLAMMATION; SIMVASTATIN; INHIBITION; REDUCTION; PLATELETS;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Expression of cellular adhesion molecules on leukocytes plays a key role in coronary artery disease (CAD). The aim of the present study was to assess whether atorvastatin therapy has an impact on the expression of cellular adhesion molecules on leukocytes in patients with normocholesterolemic CAD. Patients and Methods: In 54 patients with CAD and atorvastatin treatment and 54 CAD patients without atorvastatin therapy, expression of CD40L, CD11a, CD11b, CD54, CD62L and CD41 on leukocytes was measured using flow cytometry. All patients were normocholesterolemic. Results: Atorvastatin treatment led to a significantly lower expression of CD4OL, CD11b and CD54 on monocytes (p<0.05) and neutrophils (p<0.05). Expression of CD11a was significantly lower on monocytes (p<0.05) in atorvastatin-treated patients. Conclusion: The present results indicate that atorvastatin apparently improves chronic inflammation and may have a beneficial effect on hemostasis by reducing the expression of cellular adhesion molecules on leukocytes.
引用
收藏
页码：189 / 193
页数：5
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