Assembly of N-substituted pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones via copper catalyzed aryl amination

被引：16

作者：

Lu, Xu ^{[1
]}

Shi, Liu ^{[1
]}

Zhang, Hui ^{[1
]}

Jiang, Yongwen ^{[2
]}

Ma, Dawei ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON | 2010年 / 66卷 / 30期

基金：

中国国家自然科学基金;

关键词：

Aryl amination; Coupling; Benzodiazepine; Heterocycles; Amides; BOND FORMATION; CYCLIZATION; EFFICIENT; ARYLATION; HALIDES; ACCESS; AMINES;

D O I：

10.1016/j.tet.2010.04.127

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed amination of N-heterocycle derived aryl iodides followed by intramolecular condensative cyclization afforded N-substituted pyrrolo[2,1-c][1,4]-benzodiazepine-5,11-diones with good yields. By varying primary amines and substituents at aromatic ring of aryl iodides, a wide range of these heterocycles were assembled. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5714 / 5718

页数：5

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