Assembly of N-substituted pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones via copper catalyzed aryl amination

被引：16
|
作者：
Lu, Xu [1 ]
Shi, Liu [1 ]
Zhang, Hui [1 ]
Jiang, Yongwen [2 ]
Ma, Dawei [1 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2010年 / 66卷 / 30期
基金：
中国国家自然科学基金;
关键词：
Aryl amination; Coupling; Benzodiazepine; Heterocycles; Amides; BOND FORMATION; CYCLIZATION; EFFICIENT; ARYLATION; HALIDES; ACCESS; AMINES;
D O I：
10.1016/j.tet.2010.04.127
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed amination of N-heterocycle derived aryl iodides followed by intramolecular condensative cyclization afforded N-substituted pyrrolo[2,1-c][1,4]-benzodiazepine-5,11-diones with good yields. By varying primary amines and substituents at aromatic ring of aryl iodides, a wide range of these heterocycles were assembled. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5714 / 5718
页数：5
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