Modulation of itch and pain signals processing in ventrobasal thalamus by thalamic reticular nucleus

被引：9

作者：

Liu, Peng-Fei ^{[1
]}

Wang, Yan ^{[1
]}

Xu, Ling ^{[1
]}

Xiang, An-Feng ^{[2
]}

Liu, Ming-Zhe ^{[3
]}

Zhu, Ya-Bing ^{[1
]}

Jia, Xin ^{[2
]}

Zhang, Rui ^{[1
]}

Li, Jin-Bao ^{[1
]}

Zhang, Ling ^{[2
]}

Mu, Di ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Anesthesiol, Sch Med, Shanghai 201620, Peoples R China

[2] Tongji Univ, Rehabil Hosp Shanghai 1, Sch Med, Shanghai 200090, Peoples R China

[3] Guangzhou Med Univ, Dept Resp, Affiliated Hosp 1, Guangzhou 510120, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

NEUROPATHIC PAIN; TRACT NEURONS; LABELED LINES; INHIBITION; CIRCUIT; RAT; MECHANISMS; PROJECTION; RECEPTORS; PATTERNS;

D O I：

10.1016/j.isci.2021.103625

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thalamic reticular nucleus (TRN) is known to be crucial for dynamically modulating sensory processing. Recently, the functional role of TRN in itch and pain sensation processing has drawn much attention. We found that ventrobasal thalamus (VB) neurons exhibited scratching behavior- related and nociceptive behavior-related neuronal activity changes, and most of VB neurons responsive to pruritic stimulus were also activated by nociceptive stimulus. Inhibition of VB could relieve itch-induced scratching behaviors and pathological pain without affecting basal nociceptive thresholds, and activation of VB could facilitate scratching behaviors. Tracing and electrophysiology recording results showed that VB mainly received inhibitory inputs from ventral TRN. Furthermore, optogenetic activation of TRNVB projections suppressed scratching behaviors, and ablation of TRN enhanced scratching behaviors. In addition, activation of TRN-VB projections relieved the pathological pain without affecting basal nociceptive thresholds. Thus, our study indicates that TRN modulates itch and pain signals processing via TRN-VB inhibitory projections.

引用

页数：22

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