Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide

被引：42

作者：

Smith, AB

Freeze, BS

LaMarche, MJ

Hirose, T

Brouard, I

Rucker, PV

Xian, M

Sundermann, KF

Shaw, SJ

Burlingame, MA

Horwitz, SB

Myles, DC ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Kosan Biosci Inc, Hayward, CA 94545 USA

[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1021/ol047686a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (divided by)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamate were defined. exploiting two synthetically simplified scaffolds. as well as the parent (+)-discodermolide framework.

引用

页码：311 / 314

页数：4

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