Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress

被引：95

作者：

Sousa-Lopes, A

Antunes, F

Cyrne, L

Marinho, HS ^{[1
]}

机构：

[1] Ctr Quim & Bioquim, Grp Bioquim Oxidantes & Antioxidantes, P-1749016 Lisbon, Portugal

[2] Univ Lisbon, Fac Ciencias, Dept Quim & Bioquim, P-1749016 Lisbon, Portugal

[3] Inst Invest Cient Bento Rocha Cabral, P-1250047 Lisbon, Portugal

来源：

FEBS LETTERS | 2004年 / 578卷 / 1-2期

关键词：

H2O2; compartmentalization; gradients; catalase; enzyme latency; exponential phase; cell survival;

D O I：

10.1016/j.febslet.2004.10.090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The higher resistance of stationary-phase Saccharomyces cerevisiae to H2O2 when compared with exponential phase is well characterized, but the molecular mechanisms underlying it remain mostly unknown. By applying the steady-state H2O2 delivery model, we show that (a) cellular permeability to H2O2 is five times lower in stationary - than in exponential phase; (b) cell survival to H2O2 correlates with H2O2 cellular gradients for a variety of cells; and, (c) cells in stationary phase are predicted to be more susceptible to intracellular H2O2 than in exponential phase. In conclusion, limiting H2O2 diffusion into cells is a key protective mechanism against extracellular H2O2. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：152 / 156

页数：5

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