Sonodynamic effects of hematoporphyrin monomethyl ether on Staphylococcus aureus in vitro

被引：41

作者：

Zhuang, Deshu ^{[1
]}

Hou, Chunyan ^{[1
]}

Bi, Liangjia ^{[1
]}

Han, Jialong ^{[1
]}

Hao, Yanru ^{[2
]}

Cao, Wenwu ^{[3
]}

Zhou, Qi ^{[3
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 4, Dept Stomatol, Harbin, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Stomatol, Harbin, Peoples R China

[3] Harbin Inst Technol, Condensed Matter Sci & Technol Inst, Harbin 150006, Peoples R China

来源：

FEMS MICROBIOLOGY LETTERS | 2014年 / 361卷 / 02期

关键词：

sonodynamic antimicrobial chemotherapy; hematoporphyrin monomethyl ether; Staphylococcus aureus; ultrasound; LOW-INTENSITY ULTRASOUND; PROTOPORPHYRIN IX; THERAPY; APOPTOSIS; ANTIBIOTICS; EVOLUTION;

D O I：

10.1111/1574-6968.12628

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aims to investigate the effect of hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic antimicrobial chemotherapy (SACT) on Staphylococcus aureus. SACT was carried out using HMME and 1MHz ultrasound irradiation. The bactericidal effect was evaluated by the counting colony-forming units (CFU), and important SACT parameters including ultrasound intensity and HMME concentration were determined. More than 95% of the bacteria colonies were effectively killed in the SACT group by 50gmL(-1) HMME combined with 6Wcm(-2) tone-burst ultrasound at 1MHz, but this ultrasound level without HMME only reduced CFU by 38%. In the sonodynamic treatment, higher HMME concentrations and higher ultrasound intensities caused more death of bacteria. Incubation with different HMME concentrations without ultrasound showed no effect. Our results show that the HMME-mediated SACT can be significantly in killing S.aureus.

引用

页码：174 / 180

页数：7

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