Improving and targeting nicotine replacement therapy (NRT) are cost-effective strategies for reducing adverse health consequences for smokers. Treatment studies document the efficacy of precessation NRT and support important roles for level of nicotine dependence and precessation smoking reduction in successful quitting. However, prior work has not identified the optimal precessation dose or means for personalizing NRT. Genome-wide association has identified groups of genomic markers associated with successful quitting, allowing us to develop a v1.0 "quit-success" genotype score. We now report influences of v1.0 quit-success genotype score, level of dependence and precessation smoking reduction in a smoking cessation trial that examined effects of 21 versus 42 mg/24 h precessation NRT. Four hundred seventy-nine smokers were randomized to 21 or 42 mg NRT, initiated 2 wks prior to target quit dates. We monitored self-reported abstinence and end-expired air carbon monoxide (CO). Genotyping used Affymetrix arrays (Santa Clara, CA, USA). The primary outcome was 10-wk continuous smoking abstinence. NRT dose, level of nicotine dependence and genotype scores displayed significant interactive effects on successful quitting. Successful abstinence also was predicted by CO reductions during precessation NRT. These results document ways in which smoking cessation strategies can be personalized based on levels of nicotine dependence, genotype scores and CO monitoring. These assessments, taken together, can help match most smokers with optimal NRT doses and help rapidly identify some who may be better treated using other methods. (C) 2010 The Feinstein Institute for Medical Research, www.feinsteininstitute.org
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Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
Sch Social & Community Med, Bristol BS8 2BN, Avon, EnglandUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
Ware, Jennifer J.
Aveyard, Paul
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Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford OX2 6GG, EnglandUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
Aveyard, Paul
Broderick, Peter
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Inst Canc Res, Div Genet & Epidemiol, Sutton SM2 5NG, Surrey, EnglandUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
Broderick, Peter
Houlston, Richard S.
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Inst Canc Res, Div Genet & Epidemiol, Sutton SM2 5NG, Surrey, EnglandUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
Houlston, Richard S.
Eisen, Timothy
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Addenbrookes Hosp, Cambridge Univ Hlth Partners, Cambridge CB2 0QQ, EnglandUniv Bristol, MRC Integrat Epidemiol Unit IEU, Bristol BS8 2BN, Avon, England
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UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
UCL, Canc Res UK Hlth Behav Res Ctr, Dept Epidemiol & Publ Hlth, London, EnglandUCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
Beard, Emma
West, Robert
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UCL, Canc Res UK Hlth Behav Res Ctr, Dept Epidemiol & Publ Hlth, London, EnglandUCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
West, Robert
Michie, Susan
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UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, EnglandUCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
Michie, Susan
Brown, Jamie
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UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
UCL, Canc Res UK Hlth Behav Res Ctr, Dept Epidemiol & Publ Hlth, London, EnglandUCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 7HB, England
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Kaohsiung Municipal Kai Syuan Psychiat Hosp, Dept Addict Sci, 130,Kaisyuan 2nd Rd, Kaohsiung 802, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Wu, Hung-Chi
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Hsu, Chih-Wei
Lei, Wei-Te
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Mackay Mem Hosp, Dept Pediat, Div Allergy, Immunol,Rheumatol Dis, Hsinchu, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Lei, Wei-Te
Stubbs, Brendon
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South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England
Kings Coll London, IoPPN, Dept Psychol Med, De Crespigny Pk, London, England
Anglia Ruskin Univ, Fac Hlth Social Care & Educ, PARI, Chelmsford, Essex, EnglandI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Stubbs, Brendon
Carvalho, Andre F.
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Univ Toronto, Dept Psychiat, Toronto, ON, Canada
CAMH, Toronto, ON, CanadaI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Carvalho, Andre F.
Liang, Chih-Sung
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Triserv Gen Hosp, Dept Psychiat, Beitou Branch, Taipei, Taiwan
Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Natl Def Med Ctr, Grad Inst Med Sci, Taipei, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Liang, Chih-Sung
Yeh, Ta-Chuan
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Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Triserv Gen Hosp, Dept Psychiat, Taipei, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Yeh, Ta-Chuan
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Chen, Tien-Yu
Chu, Che-Sheng
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Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan
Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol, Kaohsiung, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Chu, Che-Sheng
Li, Juo-Chi
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Taipei Vet Gen Hosp, Dept Psychiat, Taipei, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Li, Juo-Chi
Yu, Chia-Ling
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Chang Gung Mem Hosp, Dept Pharm, Taoyuan, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Yu, Chia-Ling
Chen, Yen-Wen
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Prospect Clin Otorhinolaryngol & Neurol, Kaohsiung, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
Chen, Yen-Wen
Li, Dian-Jeng
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Kaohsiung Municipal Kai Syuan Psychiat Hosp, Dept Addict Sci, 130,Kaisyuan 2nd Rd, Kaohsiung 802, TaiwanI Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan
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Seoul Natl Univ, Inst Pharmaceut Sci, Coll Pharm & Res, Seoul 151742, South KoreaYeungnam Univ, Coll Pharm, Kyongsan 712749, Gyeongsangbuk D, South Korea
机构:
Ankara Yildirim Beyazit Univ, Fac Med, Dept Chest Dis, Ankara, Turkiye
Ankara Bilkent City Hosp, Dept Chest Dis, Ankara, TurkiyeAnkara Yildirim Beyazit Univ, Fac Med, Dept Chest Dis, Ankara, Turkiye
Sertcelik, Umran Ozden
Karalezli, Aysegul
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Ankara Yildirim Beyazit Univ, Fac Med, Dept Chest Dis, Ankara, Turkiye
Ankara Bilkent City Hosp, Dept Chest Dis, Ankara, TurkiyeAnkara Yildirim Beyazit Univ, Fac Med, Dept Chest Dis, Ankara, Turkiye