Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

被引:106
|
作者
Rose, Jed E. [1 ]
Behm, Frederique M.
Drgon, Tomas [2 ]
Johnson, Catherine [2 ]
Uhl, George R. [2 ]
机构
[1] Duke Univ, Ctr Nicotine & Smoking Cessat Res, Dept Psychiat, Durham, NC 27705 USA
[2] NIDA, Mol Neurobiol Branch, NIH, IRP, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
WHOLE-GENOME ASSOCIATION; MOLECULAR-GENETICS; WIDE ASSOCIATION; REPLACEMENT THERAPY; VULNERABILITY LOCI; VARENICLINE; RISK; VALIDATION; ABSTINENCE; BUPROPION;
D O I
10.2119/molmed.2009.00159
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Improving and targeting nicotine replacement therapy (NRT) are cost-effective strategies for reducing adverse health consequences for smokers. Treatment studies document the efficacy of precessation NRT and support important roles for level of nicotine dependence and precessation smoking reduction in successful quitting. However, prior work has not identified the optimal precessation dose or means for personalizing NRT. Genome-wide association has identified groups of genomic markers associated with successful quitting, allowing us to develop a v1.0 "quit-success" genotype score. We now report influences of v1.0 quit-success genotype score, level of dependence and precessation smoking reduction in a smoking cessation trial that examined effects of 21 versus 42 mg/24 h precessation NRT. Four hundred seventy-nine smokers were randomized to 21 or 42 mg NRT, initiated 2 wks prior to target quit dates. We monitored self-reported abstinence and end-expired air carbon monoxide (CO). Genotyping used Affymetrix arrays (Santa Clara, CA, USA). The primary outcome was 10-wk continuous smoking abstinence. NRT dose, level of nicotine dependence and genotype scores displayed significant interactive effects on successful quitting. Successful abstinence also was predicted by CO reductions during precessation NRT. These results document ways in which smoking cessation strategies can be personalized based on levels of nicotine dependence, genotype scores and CO monitoring. These assessments, taken together, can help match most smokers with optimal NRT doses and help rapidly identify some who may be better treated using other methods. (C) 2010 The Feinstein Institute for Medical Research, www.feinsteininstitute.org
引用
收藏
页码:247 / 253
页数:7
相关论文
共 36 条
  • [21] The Interaction of Smoking Cessation Norms and Nicotine Dependence on Quit Attempts: Gender-Stratified Results for Low-Income Smokers in Baltimore, MD
    Crossnohere, Norah L.
    Davey-Rothwell, Melissa
    Latkin, Carl
    Tseng, Tuo-Yen
    Czaplicki, Lauren
    Knowlton, Amy
    SUBSTANCE USE & MISUSE, 2020, 55 (03) : 424 - 428
  • [22] The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt
    Ware, Jennifer J.
    Aveyard, Paul
    Broderick, Peter
    Houlston, Richard S.
    Eisen, Timothy
    Munafo, Marcus R.
    DRUG AND ALCOHOL DEPENDENCE, 2015, 151 : 236 - 240
  • [23] An integration of parents and best friends smoking, smoking-specific cognitions, and nicotine dependence in relation to readiness to quit smoking: A comparison between adolescents with and without asthma
    van Zundert, Rinka M. P.
    Engels, Rutger C. M. E.
    Kleinjan, Marloes
    van den Eijnden, Regina J. J. M.
    JOURNAL OF PEDIATRIC PSYCHOLOGY, 2008, 33 (08) : 821 - 832
  • [24] Associations between Nicotine Dependence , Smartphone Usage Patterns, and Expected Compliance with a Smoking Cessation Application among Smokers
    Kwon, Oh Beom
    Jung, Chihoon
    Kim, Auk
    Park, Sang Won
    Byeon, Gihwan
    Lee, Seung-Joon
    Kim, Woo Jin
    HEALTHCARE INFORMATICS RESEARCH, 2024, 30 (03) : 224 - 233
  • [25] Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy, and use of stop smoking services in England: time series analysis of population trends
    Beard, Emma
    West, Robert
    Michie, Susan
    Brown, Jamie
    BMJ-BRITISH MEDICAL JOURNAL, 2016, 354 : i4645
  • [26] Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta-analysis
    Hsieh, Meng-Tsang
    Tseng, Ping-Tao
    Wu, Yi-Cheng
    Tu, Yu-Kang
    Wu, Hung-Chi
    Hsu, Chih-Wei
    Lei, Wei-Te
    Stubbs, Brendon
    Carvalho, Andre F.
    Liang, Chih-Sung
    Yeh, Ta-Chuan
    Chen, Tien-Yu
    Chu, Che-Sheng
    Li, Juo-Chi
    Yu, Chia-Ling
    Chen, Yen-Wen
    Li, Dian-Jeng
    OBESITY REVIEWS, 2019, 20 (06) : 895 - 905
  • [27] Associations between compliance with very low nicotine content (VLNC) cigarettes, abstinence self-efficacy, and quit outcomes in a pilot smoking cessation trial
    Giummo, Ryann
    Oliver, Jason A.
    McClernon, F. Joseph
    Sweitzer, Maggie M.
    DRUG AND ALCOHOL DEPENDENCE, 2024, 262
  • [28] Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis
    Choi, Hye Duck
    Shin, Wan Gyoon
    PHARMACOGENOMICS, 2015, 16 (16) : 1879 - 1885
  • [29] The association between nicotine dependence and sleep quality in patients referred to a smoking cessation outpatient clinic: A cross-sectional study
    Sertcelik, Umran Ozden
    Karalezli, Aysegul
    TOBACCO INDUCED DISEASES, 2024, 22
  • [30] Associations between nicotine vaping uptake and cigarette smoking cessation vary by smokers' plans to quit: longitudinal findings from the International Tobacco Control Four Country Smoking and Vaping Surveys
    Kasza, Karin A.
    Hammond, David
    Gravely, Shannon
    O'Connor, Richard J.
    Meng, Gang
    East, Katherine
    Borland, Ron
    Cummings, K. Michael
    Fong, Geoffrey T.
    Hyland, Andrew
    ADDICTION, 2023, 118 (02) : 340 - 352