Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy

被引:17
|
作者
Zeng, Ruijie [1 ,2 ]
Wang, Jinghua [3 ]
Zhuo, Zewei [1 ]
Luo, Yujun [1 ]
Sha, Weihong [1 ]
Chen, Hao [1 ]
机构
[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Gastroenterol, Guangzhou 510080, Peoples R China
[2] Shantou Univ, Med Coll, Shantou 515041, Peoples R China
[3] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Hematol, Guangzhou 510080, Peoples R China
基金
中国国家自然科学基金;
关键词
Stem cell; Exosome; Breast milk; Necrotizing enterocolitis; ENTERIC NERVOUS-SYSTEM; INTESTINAL EPITHELIAL-CELLS; HUMAN BREAST-MILK; EXTRACELLULAR VESICLES; AMNIOTIC-FLUID; GROWTH-FACTOR; PATHOGENESIS; EFFICACY; BIOLOGY; PROTECT;
D O I
10.1186/s13287-021-02389-4
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Necrotizing enterocolitis (NEC) is a devastating disease predominately affecting neonates. Despite therapeutic advances, NEC remains the leading cause of mortality due to gastrointestinal conditions in neonates. Stem cells have been exploited in various diseases, and the application of different types of stem cells in the NEC therapy is explored in the past decade. However, stem cell transplantation possesses several deficiencies, and exosomes are considered potent alternatives. Exosomes, especially those derived from stem cells and breast milk, demonstrate beneficial effects for NEC both in vivo and in vitro and emerge as promising options for clinical practice. In this review, the function and therapeutic effects of stem cells and exosomes for NEC are investigated and summarized, which provide insights for the development and application of novel therapeutic strategies in pediatric diseases. Further elucidation of mechanisms, improvement in preparation, bioengineering, and administration, as well as rigorous clinical trials are warranted.
引用
收藏
页数:14
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