Simplified, High Drug-Loaded Formulations Containing Hydrochlorothiazide for Twin-Screw Granulation

被引：4
|
作者：
Meier, Robin [1 ]
Moll, Klaus-Peter [2 ]
Krumme, Markus [2 ]
Kleinebudde, Peter [1 ]
机构：
[1] Heinrich Heine Univ, Inst Pharmaceut & Biopharmaceut, Univ Str 1, D-40225 Dusseldorf, Germany
[2] Novartis AG, CH-4002 Basel, Switzerland
来源：
CHEMIE INGENIEUR TECHNIK | 2017年 / 89卷 / 08期
关键词：
Continuous manufacturing; Disintegration; Granule size distribution; Hydrochlorothiazide; Tableting; WET-GRANULATION; QUALITY; ATTRIBUTES; IMPACT;
D O I：
10.1002/cite.201600134
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Simplified, high drug loaded formulations for use in twin-screw granulation and tableting were introduced, using the plastically deforming drug ibuprofen. This concept was enlarged by application of hydrochlorothiazide, because opposed deformation behavior was expected to result in different product performances. In most instances the results differed. Critical quality attributes like granule size distribution, disintegration time, and tensile strength of tablets could be met. The study confirms the suitability of simplified formulation with differently behaving drugs for pharmaceutical product design in continuous manufacturing.
引用
收藏
页码：1025 / 1033
页数：9
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