Probe with large Stokes shift for effective cysteine imaging in living cells

被引：16

作者：

Zou, Fengxia ^{[1
]}

Wang, Chun ^{[2
,3
]}

Song, Wenwu ^{[1
]}

Shen, Lujie ^{[1
]}

Xu, Runsheng ^{[1
]}

Wang, Miao ^{[1
,3
]}

Wang, Minmin ^{[1
,3
]}

Sun, Tongming ^{[1
]}

Wang, Jin ^{[1
,3
]}

机构：

[1] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China

[2] Nantong Univ, Sch Text & Clothing, Nantong 226001, Peoples R China

[3] Nantong Key Lab Intelligent & New Energy Mat, Nantong 226001, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2021年 / 257卷

基金：

中国国家自然科学基金;

关键词：

Cys detection; Coumarin; Large Stokes shift; ESIPT; Cell imaging; ENABLES SIMULTANEOUS DETECTION; ESIPT FLUORESCENT-PROBE; TURN-ON DETECTION; SELECTIVE DETECTION; DISCRIMINATION; CYS;

D O I：

10.1016/j.saa.2021.119775

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A new fluorescence probe L, which featured with a large Stokes shift (216 nm), was designed for sensitive detection of cysteine (Cys) and a potential sensing mechanism derived from excited state intramolecular proton transfer (ESIPT) was proposed. More importantly, probe L exhibits higher selective to Cys than other amino acid due to its specific cyclization between acrylate group and Cys. Meanwhile, the probe L shows a low detection limit of 8.82 x 10(8) M, which is enough for detecting Cys in organisms. Furthermore, this probe displays high biocompatibility and can image Cys in living cells. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：6

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