Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

被引：1
|
作者：
Paudel, Babita [1 ,3 ]
Bhattarai, Hari Datta [1 ]
Lee, Hong Kum [1 ]
Oh, Hyuncheol [2 ]
Shin, Hyun Woung [3 ]
Yim, Joung Han [1 ]
机构：
[1] KOPRI, Korea Polar Res Inst, Polar BioCtr, Inchon 406840, South Korea
[2] Silla Univ, Coll Med & Life Sci, Pusan 617736, South Korea
[3] Soonchunhyang Univ, Dept Marine Biotechnol, Asan 336745, South Korea
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2010年 / 65卷 / 1-2期
关键词：
Antimicrobial; Antarctic Lichen; Rumalina terebrata; Usnic Acid; ANTIMICROBIAL ACTIVITY; (-)-USNIC ACID; IN-VITRO; METABOLITES; CONSTITUENTS; BACTERIA;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of five compounds, usnic acid, usimine A, usimine B, usimine C. and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method While the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 mu g/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis,
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页码：34 / 38
页数：5
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