Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery

被引：49
|
作者：
Xu, Long [1 ]
Zhao, Mingying [2 ]
Gao, Wenxia [3 ]
Yang, Yidi [4 ]
Zhang, Jianfeng [1 ]
Pu, Yuji [4 ]
He, Bin [4 ]
机构：
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
[2] Sichuan Univ, Sch Chem Engn, Chengdu 610065, Sichuan, Peoples R China
[3] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
[4] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 181卷
基金：
中国国家自然科学基金;
关键词：
ROS-responsive; Poly(ester-thioether); Drug delivery; Nanoparticles; PEG-PCL NANOPARTICLES; HYDROGEN-PEROXIDE; GENE DELIVERY; EFFICIENT; CANCER; DOXORUBICIN; MICELLES; RELEASE; ACID; INFLAMMATION;
D O I：
10.1016/j.colsurfb.2019.05.064
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Thioketal and thioether are moieties used to fabricate reactive oxygen species (ROS)-responsive polymers for drug delivery. In this paper, three amphiphilic copolymers of mPEG-poly(ester-thioether), mPEG-poly(thioketalester) and mPEG-poly(thioketal-ester-thioether) were synthesized. The ROS-responsive behaviors of the three copolymers nanoparticles as drug carriers were investigated. The ROS-sensitivity was demonstrated by NMR, DLS, and SEM. mPEG-poly(ester-thioether) nanoparticles exhibited the fastest drug release rate, which possessed the best ROS sensitivity. The in vitro anticancer activity of the DOX-loaded nanoparticles was studied, the results revealed that the mPEG-poly(ester-thioether) nanoparticles showed the most efficient anticancer activity. Notably, all the three ROS-responsive copolymers nanoparticles showed enhanced cellular uptake and anticancer efficacy comparing to the control mPEG-b-PCL nanoparticles.
引用
收藏
页码：252 / 260
页数：9
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