Genetic Predisposition to Development of Atrial Fibrillation in Patients With Hypertensive Disease

We studied associations of genes of adrenoreceptor types 1, 2 and 3 (ADRB1, ADRB2, ADRB3), connexin (CX40) and voltage gated potassium channel type 2 (KCNH2) with development of atrial fibrillation (AF) in patients with hypertensive disease. We examined 102 patients with hypertensive disease which in 51 was complicated with AF. The groups were comparable by sex, age, Ketle index, presence of concomitant diseases. We determined alleles and genotypes of polymorphic markers G(-44)A and A71G of CX40 gene, Lys897Thr of KCNH2 gene, Ser49Gly of ADRB1 gene, Trp64Arg of ADRB3 gene with the help of PCR. Left atrial volume turned out to be significantly higher in patients with AF (88.7 +/- 4.13 ml and 65.4 +/- 3.96 ml, respectively, p=0.001). No associations of genotypes of polymorphic markers Ser49Glu of ADRB1 gene, G(-44)A and A71G of CX40 gene, Lys897Thr of KCNH2 gene, with emergence of AF in patients with arterial hypertension were revealed. For polymorphic marker Trp64Arg of ADRB3 gene frequency of Trp allele turned out to be significantly higher (OR 2.20, p=0.0176), while frequency of Arg allele significantly lower (OR 0.43, p=0.0176) in the group of patients with AF. In patients with AF frequency of Arg/Arg genotype turned out to be significantly lower (OR 0.24, p=0.0257).