Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes Enabled by an Electron-Donor Acceptor Complex of Togni's Reagent with a Tertiary Amine

被引：132
|
作者：
Cheng, Yuanzheng [1 ]
Yu, Shouyun [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 12期
基金：
中国国家自然科学基金;
关键词：
CHARGE-TRANSFER COMPLEXES; CATALYTIC HYDROTRIFLUOROMETHYLATION; TRIFLUOROMETHYLATION REACTIONS; RADICAL TRIFLUOROMETHYLATION; LIGHT-IRRADIATION; ALPHA-ALKYLATION; EDA COMPLEXES; PERFLUOROALKYLATION; CYCLOADDITION; IODOTRIFLUOROMETHYLATION;
D O I：
10.1021/acs.orglett.6b01301
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An electron-donor acceptor (EDA) complex between Togni's reagent and a tertiary amine has been introduced. The existence of this EDA complex was supported by NMR titration experiments. The hydrotrifluoromethylation of unactivated aliphatic alkenes and alkynes enabled by this EDA complex has also been developed. This hydrotrifluoromethylation protocol is operationally simple and, promoted by a tertiary amine.
引用
收藏
页码：2962 / 2965
页数：4
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