Prostate-specific Membrane Antigen PET in Prostate Cancer

被引：49

作者：

Lawhn-Heath, Courtney ^{[1
]}

Salavati, Ali ^{[3
]}

Behr, Spencer C. ^{[1
,2
]}

Rowe, Steven P. ^{[3
]}

Calais, Jeremie ^{[4
]}

Fendler, Wolfgang P. ^{[5
,6
]}

Eiber, Mattias ^{[7
]}

Emmett, Louise ^{[8
]}

Hofman, Michael S. ^{[9
,10
]}

Hope, Thomas A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 505 Parnassus Ave,M391, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, 505 Parnassus Ave,M391, San Francisco, CA 94143 USA

[3] Johns Hopkins Univ, Dept Radiol & Radiol Sci, Baltimore, MD USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Theranost Div, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Univ Duisburg Essen, Dept Nudear Med, Essen, Germany

[6] Univ Hosp Essen, German Canc Consortium DKTK, Essen, Germany

[7] Tech Univ Munich, Dept Nucl Med, Munich, Germany

[8] St Vincents Hosp, Dept Theranost & Nucl Med, Sydney, NSW, Australia

[9] Peter MacCallum Canc Ctr, Prostate Theranost & Imaging Ctr Excellence ProsT, Melbourne, Vic, Australia

[10] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

来源：

RADIOLOGY | 2021年 / 299卷 / 02期

关键词：

I-AND-T; BIOCHEMICAL RECURRENCE; RADIATION-DOSIMETRY; RADICAL PROSTATECTOMY; GA-68-PSMA-11; PET/CT; BIODISTRIBUTION; RADIOTHERAPY; THERAPY; MEN; RECOMMENDATIONS;

D O I：

10.1148/radiol.2021202771

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals are playing a large role at the time of initial staging and biochemical recurrence for localizing prostate cancer, as well as in other emerging clinical settings. PSMA PET has demonstrated increased detection rate compared with conventional imaging and has been shown to change management plans in a substantial percentage of cases. The aims of this narrative review are to highlight the development and clinical impact of PSMA PET-radiopharmaceuticals, to compare PSMA to other agents such as fluorine 18 fluciclovine and carbon 11 choline, and to highlight some of the individual PSMA PET agents that have contributed to the advancement of prostate cancer imaging. (C) RSNA, 2021

引用

页码：248 / 260

页数：13

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