Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tu 6040 I.: Taxonomy, fermentation, isolation and biological activities

被引：62
|
作者：
Schimana, J
Fiedler, HP
Groth, I
Süssmuth, R
Beil, W
Walker, M
Zeeck, A
机构：
[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany
[2] Hans Knoll Inst Naturstoff Forsch EV, D-07745 Jena, Germany
[3] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
[4] Med Hsch Hannover, Inst Pharmakol, D-30625 Hannover, Germany
[5] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany
来源：
JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 08期
关键词：
D O I：
10.7164/antibiotics.53.779
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tu 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.
引用
收藏
页码：779 / 787
页数：9
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