Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing

被引：11
|
作者：
Fouad, Hanan H. [2 ]
Al-Dera, Husain [3 ]
Bakhoum, Sameh W. [4 ]
Rashed, Laila A. [2 ]
Sayed, Rehab H. [2 ]
Rateb, Moshira A. [5 ]
Haidara, Mohamed A. [1 ]
Soskic, Sanja [6 ]
Isenovic, Esma R. [6 ]
机构：
[1] King Khalid Univ, Dept Physiol, Coll Med, Abha, Saudi Arabia
[2] Cairo Univ, Dept Med Biochem, Kasr Al Aini Fac Med, Giza, Egypt
[3] King Saud bin Abdulaziz Univ Hlth Sci, Dept Physiol, Coll Med, Riyadh, Saudi Arabia
[4] Cairo Univ, Dept Cardiol, Kasr Al Aini Fac Med, Giza, Egypt
[5] Cairo Univ, Dept Physiol, Kasr Al Aini Fac Med, Giza, Egypt
[6] Univ Belgrade, Dept Mol Genet & Radiobiol, Vinca Inst, Belgrade, Serbia
来源：
ANGIOLOGY | 2010年 / 61卷 / 06期
关键词：
coronary artery disease; acute coronary syndrome; CD40; ligand; coronary angiogram; UNSTABLE ANGINA-PECTORIS; C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; SERUM NEOPTERIN LEVELS; SMOOTH-MUSCLE-CELLS; CD40; LIGAND; ENDOTHELIAL-CELLS; TISSUE FACTOR; MATRIX METALLOPROTEINASES; CARDIOVASCULAR-DISEASE;
D O I：
10.1177/0003319709356785
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
We determined the serum levels of soluble CD40 ligand (sCD4OL) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P < .001) of sCD4OL compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 +/- 2.92, MI: 7.38 +/- 1.05, SA: 4.42 +/- 1.08; control: 4.01 +/- 0.87 ng/mL). There was no significant difference in sCD4OL levels between patients with UA and MI or between patients with SA and controls. Levels of sCD4OL did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS.
引用
收藏
页码：567 / 573
页数：7
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