Parasites and asthma

被引：7
|
作者：
Lin Wuhao [1 ,2 ]
Chen Ran [1 ,2 ]
He Xujin [3 ]
Wu Zhongdao [1 ,2 ,4 ]
Dekumyoy, Paron [5 ]
Lv Zhiyue [1 ,2 ,4 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Sch Med, 74 2nd Zhongshan Rd, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Guangdong, Peoples R China
[3] South China Normal Univ, Affiliated High Sch, Guangzhou 510630, Guangdong, Peoples R China
[4] Prov Engn Technol Res Ctr Biol Vector Control, Guangzhou 510080, Guangdong, Peoples R China
[5] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand
来源：
PARASITOLOGY RESEARCH | 2017年 / 116卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Parasite; Asthma; Prevention; Therapy; ALLERGIC AIRWAY INFLAMMATION; REGULATORY T-CELLS; PLACEBO-CONTROLLED TRIAL; TICK SALIVARY PROTEIN; SKIN-TEST REACTIVITY; GEOHELMINTH INFECTIONS; SCHISTOSOMA-JAPONICUM; MULTIPLE-SCLEROSIS; HELMINTH INFECTION; IMMUNE-RESPONSES;
D O I：
10.1007/s00436-017-5548-1
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Nowadays, many studies have found low morbidity of asthma in epidemic areas of parasitic diseases, as shown by the hygiene hypothesis. It is obvious that some parasite infections can prevent asthma and studies have been carried out to clarify the mechanism of the preventive effect and search for the future asthmatic therapies. Previous findings have indicated that this mechanism may be related to the immune response switching from Th1 to Th2 and important cells induced by parasites, including the regulatory T cells, regulatory B cells, dendrite cells, and alternatively activated macrophages. Cytokine IL-10 also plays a nonredundant role in protection against allergic airway inflammation in asthma. This review focuses on the relationship between parasites and asthma, and the potential protection mechanism involved.
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页码：2373 / 2383
页数：11
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