Neurotrophin-mediated rapid signaling in the central nervous system: Mechanisms and functions

被引：184
|
作者：
Blum, R [1 ]
Konnerth, A [1 ]
机构：
[1] Univ Munich, Inst Physiol, Munich, Germany
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00042.2004
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.
引用
收藏
页码：70 / 78
页数：9
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