Subclinical hyperthyroidism and sudden unexpected death in epilepsy

被引：2

作者：

Scorza, Fulvio A. ^{[1
]}

Arida, Ricardo M. ^{[2
]}

Cysneiros, Roberta M. ^{[3
]}

Terra, Vera C. ^{[4
]}

de Albuquerque, Manly ^{[1
]}

Machado, Helio R. ^{[4
]}

Cavalheiro, Esper A. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Disciplina Neurol Expt, EPM, BR-04023900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Fisiol, EPM, BR-04023900 Sao Paulo, Brazil

[3] Univ Presbiteriana Mackenzie, Programa Posgrad Distrubios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, Brazil

[4] Univ Sao Paulo, CIREP, Dept Neurociencias & Ciencias Comportamento, Fac Med Ribeirao Preto, Sao Paulo, Brazil

来源：

MEDICAL HYPOTHESES | 2010年 / 74卷 / 04期

关键词：

UNEXPLAINED DEATH; THYROID-FUNCTION;

D O I：

10.1016/j.mehy.2009.10.045

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role. In parallel, several studies have shown a link between hormones and epilepsy. However, exact knowledge regarding the association of thyroid hormones and epilepsy is lacking. As subclinical hyperthyroidism has been linked with increased risk of cardiovascular disease, we propose in this paper that SUDEP, at least in some cases, could be related with subclinical thyroid dysfunction. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：692 / 694

页数：3

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