VBP-1 is necessary for morphogenesis in Caenorhabditis elegans

被引：0
|
作者：
Ichimiya, H
Hino, O
Kohara, Y
Ishii, N [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Mol Life Sci, Isehara, Kanagawa 2591193, Japan
[2] Japanese Fdn Canc Res, Inst Canc, Dept Expt Pathol, Toshima Ku, Tokyo 1708455, Japan
[3] Natl Inst Genet, Gene Network Lab, Mishima, Shizuoka 4118540, Japan
来源：
ONCOLOGY REPORTS | 2003年 / 10卷 / 02期
关键词：
VBP-1; VHL; C; elegans; embryogenesis; morphogenesis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
VBP-1 has been isolated as a novel protein binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. The fundamental function of the gene was examined in the nematode, Caenorhabditis elegans (C. elegans). The C. elegans VBP-1 gene was expressed in adults only in the gonads and was also expressed in early stage embryos. Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis.
引用
收藏
页码：293 / 295
页数：3
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