First Tissue-Agnostic Drug Approval Issued

被引：28
|
作者：
Poh, Alissa
机构：
来源：
CANCER DISCOVERY | 2017年 / 7卷 / 07期
关键词：
D O I：
10.1158/2159-8290.CD-NB2017-078
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The PD-1 inhibitor pembrolizumab received accelerated approval for adult and pediatric patients with solid tumors that are mismatch repair-deficient or microsatellite instability-high. This is the first time the FDA has greenlighted a drug based not on tumor type, but on a common biomarker. ©2017 American Association for Cancer Research.
引用
收藏
页码：656 / 656
页数：1
相关论文
共 50 条
  • [41] FDA clears a tissue-agnostic cancer drug Bayer and Loxo's treatment will carry a hefty price tag
    Jarvis, Lisa M.
    CHEMICAL & ENGINEERING NEWS, 2018, 96 (48) : 14 - 14
  • [42] Considering molecular alterations as pan-cancer tissue-agnostic targets
    Adashek, Jacob J.
    Kato, Shumei
    Sicklick, Jason K.
    Lippman, Scott M.
    Kurzrock, Razelle
    NATURE CANCER, 2023, 4 (12) : 1622 - 1626
  • [43] First tumor-agnostic approval for an ADC
    O'Leary, Karen
    NATURE MEDICINE, 2024, 30 (12) : 3392 - 3392
  • [44] Liquid biopsy in head and neck cancers: A model for tissue-agnostic MRD detection
    Bratman, Scott V.
    CLINICAL CANCER RESEARCH, 2024, 30 (21)
  • [45] A new tissue-agnostic microfluidic device to model physiology and disease: the lattice platform
    Campo, Hannes
    Zha, Didi
    Pattarawat, Pawat
    Colina, Jose
    Zhang, Delong
    Murphy, Alina
    Yoon, Julia
    Russo, Angela
    Rogers, Hunter B.
    Lee, Hoi Chang
    Zhang, Jiyang
    Trotter, Katy
    Wagner, Sarah
    Ingram, Asia
    Pavone, Mary Ellen
    Dunne, Sara Fernandez
    Boots, Christina E.
    Urbanek, Margrit
    Xiao, Shuo
    Burdette, Joanna E.
    Woodruff, Teresa K.
    Kim, J. Julie
    LAB ON A CHIP, 2023, 23 (22) : 4821 - 4833
  • [46] Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure
    Lee, Dongwon
    Han, Seong Kyu
    Yaacov, Or
    Berk-Rauch, Hanna
    Mathiyalagan, Prabhu
    Ganesh, Santhi K.
    Chakravarti, Aravinda
    CURRENT OPINION IN FOOD SCIENCE, 2023, 54
  • [47] Real-world evidence to inform clinical insights on tissue-agnostic approvals of therapies
    Sledge, George W.
    Yoshino, Takayuki
    Xiu, Joanne
    Helmstetter, Anthony
    Klimov, Sergey
    Gilg, Brady
    Oberley, Matthew James
    Radovich, Milan
    Abraham, Jim
    Spetzler, David
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [48] From Tissue-Agnostic to N-of-One Therapies:(R)Evolution of the Precision Paradigm
    Adashek, Jacob J.
    Subbiah, Vivek
    Kurzrock, Razelle
    TRENDS IN CANCER, 2021, 7 (01): : 15 - 28
  • [49] SETD2 a potential tissue-agnostic predictive biomarker for ICIs in solid tumors
    Chen, Y.
    Zheng, X.
    Xiong, J.
    Guan, Y.
    Li, Y.
    Gao, X.
    Lin, J.
    Fei, Z.
    Chen, L.
    Chen, L.
    Chen, G.
    Yi, X.
    Cao, W.
    Ai, X.
    Zhou, C.
    Li, X.
    Zhao, J.
    Yan, X.
    Yu, Q.
    Chen, C.
    ANNALS OF ONCOLOGY, 2021, 32 : S390 - S390
  • [50] Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals
    Sledge Jr, George W.
    Yoshino, Takayuki
    Xiu, Joanne
    Helmstetter, Anthony
    Ribeiro, Jennifer R.
    Klimov, Sergey
    Gilg, Brady
    Gao, J. J.
    Elton, Jeff
    Oberley, Matthew J.
    Radovich, Milan
    Abraham, Jim
    Spetzler, David
    NATURE COMMUNICATIONS, 2025, 16 (01)
12345