Neurotrophic effects of bone morphogenetic protein-7 in a rat model of Parkinson's disease

被引：30
|
作者：
Harvey, BK [1 ]
Mark, A [1 ]
Chou, J [1 ]
Chen, GJ [1 ]
Hoffer, BJ [1 ]
Wang, Y [1 ]
机构：
[1] Natl Inst Drug Abuse, Neural Protect & Regenerat Sect, NIH, Baltimore, MD 21224 USA
来源：
BRAIN RESEARCH | 2004年 / 1022卷 / 1-2期
关键词：
bone morphogenetic protein-7; Parkinson's disease; neuroprotection;
D O I：
10.1016/j.brainres.2004.06.072
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies have demonstrated that pretreatment with bone morphogenetic protein-7 (BMP7) reduces ischemic neuronal injury in vivo. Moreover, exogenous application of BMP7 increases both the number of tyrosine hydroxylase (+) cells and dopamine (DA) uptake in rat mesencephalic cell cultures. The purpose of this study was to investigate the in vivo effects of BMP7 on 6-hydroxydopamine (6-OHDA) induced lesioning of midbrain DA neurons. Adult Fischer 344 rats were anesthetized and injected with BMP7 or vehicle into the left substantia nigra, followed by local administration of 9 mug of 6-OHDA into the left medial forebrain bundle. The lesioned animals that received BMP7 pretreatment, as compared to vehicle/6-OHDA controls, had a significant reduction in methamphetamine-induced rotation 1 month after the surgery. BMP7-pretreatment partially preserved KCl-induced dopamine release in the lesioned striatum and significantly increased TH immunoreactivity in the lesioned nigra and striatum. In summary, our data suggest that BMP7 has neuroprotective and/or neuroreparative effects against 6-OHDA lesioning of the nigrostriatal DA pathway in an animal model of Parkinson's disease (PD). Published by Elsevier B.V.
引用
收藏
页码：88 / 95
页数：8
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