The stability of blood fatty acids during storage and potential mechanisms of degradation: A review

被引：43

作者：

Metherel, Adam H. ^{[1
]}

Stark, Ken D. ^{[1
]}

机构：

[1] Univ Waterloo, 200 Univ Ave, Waterloo, ON N2L 3G1, Canada

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2016年 / 104卷

关键词：

Fatty acid; Polyunsaturated fatty acid; Storage stability; Peroxidation; Blood; LONG-TERM STORAGE; AAPH-INDUCED HEMOLYSIS; -20; DEGREES-C; LIPID-PEROXIDATION; WHOLE-BLOOD; DRIED BLOOD; BUTYLATED HYDROXYTOLUENE; DOCOSAHEXAENOIC ACID; OSMOTIC FRAGILITY; EICOSAPENTAENOIC ACID;

D O I：

10.1016/j.plefa.2015.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fatty acids in blood samples, particularly polyunsaturated fatty acids (PUFAs), are susceptible to degradation through peroxidation reactions during long-term storage. Storage of blood samples is necessary in almost all studies and is crucial for larger clinical studies and in field research settings where it is not plausible for analytical infrastructure. Despite this, PUFA stability during blood storage is often overlooked. This review introduces and discusses lipid peroxidation and popular strategies employed to prevent or minimize peroxidation reactions during fatty acid analysis. Further, an in-depth examination of fatty acid stability during storage of blood is discussed in detail for all blood fractions including plasma/serum, erythrocytes and whole blood stored both in cryovials and on chromatography paper before discussing the associated mechanisms of degradation during storage. To our knowledge this is the first review of its kind and will provide researchers with the necessary information to confidently store blood samples for fatty acid analysis. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：33 / 43

页数：11

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