(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

被引：1
|
作者：
Fortunato, Milene A. G. [1 ]
Siopa, Filipa [1 ]
Afonso, Carlos A. M. [1 ]
机构：
[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal
来源：
MOLBANK | 2021年 / 2021卷 / 02期
关键词：
aminocyclopentitol; bicyclic aziridine; water chemistry; nucleophilic substitution; PYRIDINIUM SALT PHOTOCHEMISTRY; AMINOCYCLOPENTITOLS; AZIRIDINES; INHIBITOR; VERSATILE; CYP51;
D O I：
10.3390/M1199
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio) cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via H-1, C-13-NMR, HSQC, and mass spectral data.
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页数：5
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