(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

被引：1

作者：

Fortunato, Milene A. G. ^{[1
]}

Siopa, Filipa ^{[1
]}

Afonso, Carlos A. M. ^{[1
]}

机构：

[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

来源：

MOLBANK | 2021年 / 2021卷 / 02期

关键词：

aminocyclopentitol; bicyclic aziridine; water chemistry; nucleophilic substitution; PYRIDINIUM SALT PHOTOCHEMISTRY; AMINOCYCLOPENTITOLS; AZIRIDINES; INHIBITOR; VERSATILE; CYP51;

D O I：

10.3390/M1199

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio) cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via H-1, C-13-NMR, HSQC, and mass spectral data.

引用

页数：5

共 50 条

[1] (2R, 4S, 5S) 1-(4-(4-(((7-Chloroquinolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Kuan, Houin
Xie, Yuhan
Guo, Yuzhu
Gianoncelli, Alessandra
Ribaudo, Giovanni
Coghi, Paolo
MOLBANK, 2023, 2023 (03)
[2] A 1:1 cocrystal of (1R,3S,4S,6R)-1,2,3,4,5,6-hexabromo-1,2,3,4,5,6-hexahydropentalene and (1R,2R,4S,5S)-1,2,3,4,5,6-hexabromo-1,2,4,5-tetrahydropentalene
Hokelek, Tuncer
Gunbas, Duygu D.
Algi, Fatih
Balci, Metin
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O2466 - O2468
[3] Bis[(1-methyl-1H-tetrazol-5-yl)sulfanyl]ethane
Li, Chun-Rong
Chen, Tao
Xia, Zheng-Qiang
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1669 - U523
[4] (4S,5S)-4-[(1R)-1,2-Dihydroxyethyl]-5-tridecyl-1,3-oxazolidin-2-one
Sawatzki, P
Mikeska, T
Nieger, M
Bolte, M
Kolter, T
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 2003, 59 (05) : O225 - O227
[5] Bis[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methane
Wei, Wei
Xia, Zheng-qiang
Chen, San-ping
Gao, Sheng-li
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O999 - U1602
[6] (5S)-3-Chloro-5-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-(4-methylpiperidin-1-yl)furan-2(5H)-one
Wang, Xiao-Mei
Fu, Jian-Hua
Cai, Song-Liang
Wang, Zhao-Yang
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O656 - U2075
[7] (5S)-3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-5-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]furan-2(5H)-one
Fu, Jian-Hua
Wang, Zhao-Yang
Xue, Fu-Ling
Huo, Jing-Pei
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O73 - U1942
[8] S-S BOND FORMATION REACTION USING BIS(1-METHYL-1H-TETRAZOL-5-YL) DISULFIDE
OHTANI, M
NARISADA, M
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (18): : 5475 - 5478
[9] 4-(1H-Tetrazol-5-yl)-1H-indole
Ge, Yu-Hua
Han, Pei
Wei, Ping
Ouyang, Ping-Kai
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2390 - U1001
[10] (1R*,2S*,4S*,5S*)-Cyclohexane-1,2,4,5-tetrol
Mehta, G
Sen, S
Dey, S
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O920 - O922

← 1 2 3 4 5 →