Photic stimulation-induced alteration of brain energy metabolism measured by 31P-MR spectroscopy in patients with MELAS

被引：17
|
作者：
Kato, T [1 ]
Murashita, J
Shioiri, T
Terada, M
Inubushi, T
Kato, N
机构：
[1] Univ Tokyo, Fac Med, Dept Neuropsychiat, Tokyo 113, Japan
[2] Shiga Univ Med Sci, Dept Internal Med 3, Otsu, Shiga 52021, Japan
[3] Shiga Univ Med Sci, Mol Neurobiol Res Ctr, Otsu, Shiga 52021, Japan
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 155卷 / 02期
关键词：
brain energy metabolism; MELAS (mitochondrial myopathy; encephalopathy; lactic acidosis; and stroke-like episodes); phosphocreatine; phosphorus-31 magnetic resonance spectroscopy (P-31-MRS); 3243 mitochondrial DNA mutation;
D O I：
10.1016/S0022-510X(97)00308-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We examined brain energy metabolism by phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) in the occipital cortex in a mother and a daughter with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) during photic stimulation. The peak area ratio of phosphocreatine markedly decreased during photic stimulation, and subsequently increased after the stimulation. This method, photic stimulation-P-31-MRS, may be useful in assessing brain energy metabolism in neurological diseases. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：182 / 185
页数：4
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