Evaluation of Intravenous Posaconazole Dosing and Pharmacokinetic Target Attainment in Pediatric Patients

被引：13
|
作者：
Nickless, Jenna R. [1 ]
Bridger, Kathryn E. [1 ]
Vora, Surabhi B. [2 ]
Brothers, Adam W. [1 ]
机构：
[1] Seattle Childrens Hosp, Dept Pharm, Washington, DC USA
[2] Univ Washington, Sch Med, Dept Pediat, Div Infect Dis,Seattle Childrens Hosp, Washington, DC USA
来源：
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2019年 / 8卷 / 04期
关键词：
child; hepatotoxicity; intravenous; level; posaconazole; FLUCONAZOLE; PROPHYLAXIS;
D O I：
10.1093/jpids/piy094
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Limited data exist on intravenous (IV) posaconazole dosing and the risk for hepatotoxicity it confers to children. In this study, we evaluated dosing and resulting trough levels in 10 pediatric patients on IV posaconazole. A therapeutic level in these patients was achieved 95% of the time. We found a median minimum effective dose of 6.55 mg/kg of body weight. No correlation was found between the duration or posaconazole trough level and an increased alanine transaminase level.
引用
收藏
页码：365 / 367
页数：3
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