Biological availability of inhaled fluticasone propionate in horses

被引：10
|
作者：
Laan, TTJM
Westermann, CM
Dijkstra, AV
Van Nieuwstadt, RA
Fink-Gremmels, J
机构：
[1] Univ Utrecht, Fac Vet Med, Dept Equine Sci, Internal Med Sect, NL-3508 TD Utrecht, Netherlands
[2] Univ Utrecht, Fac Vet Med, Dept Pharmacol Pharm & Toxicol, NL-3508 TD Utrecht, Netherlands
来源：
VETERINARY RECORD | 2004年 / 155卷 / 12期
关键词：
D O I：
10.1136/vr.155.12.361
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Healthy horses received aerosolised, intranasal or oral doses of 3 mg of fluticasone propionate evenly divided over morning and evening treatments for seven days. The bioavailability of the drug was determined in terms of the suppression of the endogenous cortisol concentrations in the horses during the period of treatment. The horses which received the aerosolised drug had significantly lower concentrations of endogenous cortisol on days 5 and 8 than the horses which received aerosolised placebo. The horses which received nasal and oral doses of fluticasone propionate showed no significant changes in their endogenous cortisol concentrations.
引用
收藏
页码：361 / +
页数：4
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