Diabetic kidney disease in type 2 diabetes: a review of pathogenic mechanisms, patient-related factors and therapeutic options

被引：8

作者：

Woodhams, Louise ^{[1
]}

Sim, Tin Fei ^{[1
]}

Chalmers, Leanne ^{[1
]}

Yeap, Bu ^{[2
,3
]}

Green, Daniel ^{[4
]}

Schlaich, Markus ^{[3
,5
,6
,7
]}

Schultz, Carl ^{[3
,8
]}

Hillis, Graham ^{[3
,8
]}

机构：

[1] Curtin Univ Technol, Curtin Med Sch, Perth, WA, Australia

[2] Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia

[3] Univ Western Australia, Med Sch, Perth, WA, Australia

[4] Univ Western Australia, Sch Human Sci Exercise & Sport Sci, Perth, WA, Australia

[5] Royal Perth Hosp, Dept Cardiol & Nephrol, Perth, WA, Australia

[6] Baker Heart & Diabet Inst, Neurovasc Hypertens & Kidney Dis Lab, Melbourne, Vic, Australia

[7] Univ Western Australia, Royal Perth Hosp Unit, Dobney Hypertens Ctr, Sch Med,Med Res Fdn, Perth, WA, Australia

[8] Royal Perth Hosp, Dept Cardiol, Perth, WA, Australia

来源：

PEERJ | 2021年 / 9卷

关键词：

Type 2 Diabetes Mellitus; Diabetic kidney disease; Pathogenesis; Risk factors; GLYCATION END-PRODUCTS; BODY-MASS INDEX; PODOCYTE INJURY; HEART-RATE; MINERALOCORTICOID RECEPTOR; MICROVASCULAR OUTCOMES; OXIDATIVE STRESS; GENETIC-VARIANTS; RENAL PROTECTION; ANGIOTENSIN-II;

D O I：

10.7717/peerj.11070

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The global prevalence of diabetic kidney disease is rapidly accelerating due to an increasing number of people living with type 2 diabetes. It has become a significant global problem, increasing human and financial pressures on already overburdened healthcare systems. Interest in diabetic kidney disease has increased over the last decade and progress has been made in determining the pathogenic mechanisms and patient-related factors involved in the development and pathogenesis of this disease. A greater understanding of these factors will catalyse the development of novel treatments and influence current practice. This review summarises the latest evidence for the factors involved in the development and progression of diabetic kidney disease, which will inform better management strategies targeting such factors to improve therapeutic outcomes in patients living with diabetes.

引用

页数：35

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