Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora .1. Taxonomy, fermentation, isolation, and biological activities

被引：166
|
作者：
Romero, F [1 ]
Espliego, F [1 ]
Baz, JP [1 ]
DeQuesada, TG [1 ]
Gravalos, D [1 ]
DelaCalle, F [1 ]
FernadezPuertes, JL [1 ]
机构：
[1] PHARMAMAR SA,DRUG DISCOVERY DIV,LEON 24196,SPAIN
来源：
JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 09期
关键词：
D O I：
10.7164/antibiotics.50.734
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.
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收藏
页码：734 / 737
页数：4
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