Tunable Di- and Mono-γ-C-H Arylation of Phenylacetamides by Palladium-Catalyzed Domino Reactions

被引：22
|
作者：
Liu, Yunyun [1 ]
Huang, Bin [1 ]
Cao, Xiaoji [2 ]
Wan, Jie-Ping [1 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China
[2] Zhejiang Univ Technol, Res Ctr Anal & Measurement, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China
来源：
CHEMCATCHEM | 2016年 / 8卷 / 08期
基金：
中国国家自然科学基金;
关键词：
C-H activation; domino reactions; molecular diversity; step economy; tunable selectivity; STEP-ECONOMICAL SYNTHESIS; DIRECTING GROUP; BOND FUNCTIONALIZATIONS; ARYL HALIDES; METAL; ACTIVATION; 8-AMINOQUINOLINE; SULFENYLATION; CONSTRUCTION; OLEFINATION;
D O I：
10.1002/cctc.201600039
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The Pd-catalyzed C-H arylation of phenylacetamides in the position was realized for the first time by means of a domino process consisting of insitu directing group installation and C-H arylation. Unprecedented tunable selectivity between di- and monoactivation of the two identical -C-H bonds was achieved by modifying the reaction conditions; this is a distinct feature of this one-pot procedure for the C-H-activation-based synthesis of diverse amides.
引用
收藏
页码：1470 / 1473
页数：4
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