Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

被引：17
|
作者：
Nishimura, Tomoki [1 ]
Sumi, Naoki [1 ]
Mukai, Sada-atsu [1 ]
Sasaki, Yoshihiro [1 ]
Akiyoshi, Kazunari [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 41期
关键词：
BLOCK-COPOLYMER MICELLES; CYLINDRICAL MICELLES; AQUEOUS-SOLUTIONS; POLY(2-OXAZOLINE)S; NANOPARTICLES; GELATORS; GELATION; WATER;
D O I：
10.1039/c9tb00918c
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
An approach for the preparation of self-healing and injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is reported. Hydrogelation does not require any organic solvents, as the polymers dissolve in water below their lower critical solution temperatures. The transplanted hydrogels cause no significant foreign-body response. Considering the simplicity of the method and the biocompatibility of the resulting injectable hydrogels, crystallization-driven hydrogelation of poly(oxazoline)-based polymers may potentially be used in a wide range of biomedical applications.
引用
收藏
页码：6362 / 6369
页数：8
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