Ruthenium(ii)-catalyzed synthesis of CF3-isoquinolinones via C-H activation/annulation of benzoic acids and CF3-imidoyl sulfoxonium ylides

被引：42
|
作者：
Wen, Si [1 ]
Zhang, Yuqing [1 ]
Tian, Qingyu [1 ]
Chen, Yanhui [1 ]
Cheng, Guolin [1 ]
机构：
[1] Huaqiao Univ, Xiamen Key Lab Optoelect Mat & Adv Mfg, Coll Mat Sci & Engn, Instrumental Anal Ctr, Xiamen 361021, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 16期
关键词：
REGIOSELECTIVE SYNTHESIS; ACTIVATION; BENZAMIDES; ANNULATION; FLUORINE; ALKYNES; BOND; COUPLING/CYCLIZATION; ISOQUINOLINONES; CYCLIZATION;
D O I：
10.1039/d2qo00839d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium(ii)-catalyzed C-H activation/annulation reaction of benzoic acids and CF3-imidoyl sulfoxonium ylides enabled by weak O-coordination has been achieved. A series of 3-trifluoromethylisoquinolinones were synthesized in 37-75% yields under redox-neutral reaction conditions.
引用
收藏
页码：4388 / 4393
页数：6
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