Cancer vaccines: What do we need to measure in clinical trials?

被引：8

作者：

Kudrin, Alex ^{[1
]}

机构：

[1] Celltrion Inc, Inchon, South Korea

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 11期

关键词：

cancer vaccines; endpoints; immune response; patient reported outcomes; progression free survival; SIPULEUCEL-T; IMMUNOTHERAPY; SURVIVAL; APPROVAL; THERAPY;

D O I：

10.4161/hv.27586

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer immunotherapy has seen a tremendous number of failures and only few recent regulatory successes. This review is dedicated to evaluate remaining challenges in capturing clinical response with cancer vaccines. Definition of disease progression in context of clinical rather image-specific criteria and interpretation of efficacy in relation to delayed effect of cancer vaccines should be taken into account in the design of future of immunotherapy trials.

引用

页码：3236 / 3240

页数：5

共 50 条

[41] What do we measure when we measure aggression?
Longino, HE
STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE, 2001, 32A (04): : 685 - 704
[42] Do we need [more] clinical trials in Transfusion Medicine and Hemotherapy?
Garraud, Olivier
TRANSFUSION AND APHERESIS SCIENCE, 2016, 55 (02) : 262 - 263
[43] Statins in children: what do we know and what do we need to do?
Black D.M.
Current Atherosclerosis Reports, 2001, 3 (1) : 29 - 34
[44] Do we need more clinical trials in secondary progressive MS?
不详
MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2022, 60
[45] Do we need controlled clinical trials in pulmonary arterial hypertension?
Galiè, N
EUROPEAN RESPIRATORY JOURNAL, 2001, 17 (01) : 1 - 3
[46] Do We Need More Exercise and Osteoarthritis Randomized Clinical Trials?
Messier, Stephen P.
ARTHRITIS & RHEUMATOLOGY, 2024, 76 (03) : 354 - 355
[47] Do We Really Need More Clinical Trials of Pneumatic Retinopexy?
Yorston, David
JAMA OPHTHALMOLOGY, 2021, 139 (08) : 853 - 854
[48] Do we need randomized clinical trials in extracorporeal respiratory support? No
Gattinoni, Luciano
Quintel, Michael
INTENSIVE CARE MEDICINE, 2017, 43 (12) : 1866 - 1868
[49] Do we need randomized clinical trials in extracorporeal respiratory support? No
Luciano Gattinoni
Michael Quintel
Intensive Care Medicine, 2017, 43 : 1866 - 1868
[50] Randomized clinical trials in surgery: Why do we need them?
Balch, Charles M.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2006, 132 (02): : 241 - 242

← 1 2 3 4 5 →