International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature

被引:154
|
作者
Guenther, Thomas [1 ]
Tulipano, Giovanni [2 ]
Dournaud, Pascal [3 ]
Bousquet, Corinne [4 ]
Csaba, Zsolt [3 ]
Kreienkamp, Hans-Juergen [5 ]
Lupp, Amelie [1 ]
Korbonits, Marta [6 ]
Castano, Justo P. [7 ,8 ,9 ,10 ]
Wester, Hans-Juergen [11 ]
Culler, Michael [12 ]
Melmed, Shlomo [13 ]
Schulz, Stefan [1 ]
机构
[1] Friedrich Schiller Univ, Jena Univ Hosp, Inst Pharmacol & Toxicol, Jena, Germany
[2] Univ Brescia, Dept Mol & Translat Med, Unit Pharmacol, Brescia, Italy
[3] Univ Paris Diderot, PROTECT, INSERM, Sorbonne Paris Cite, Paris, France
[4] Univ Toulouse III Paul Sabatier, Canc Res Ctr Toulouse, INSERM UMR 1037, Toulouse, France
[5] Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Hamburg, Germany
[6] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med, Ctr Endocrinol, London, England
[7] Maimonides Inst Biomed Res Cordoba, Cordoba, Spain
[8] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain
[9] Reina Sofia Univ Hosp, Cordoba, Spain
[10] CIBER Fisiopatol Obesidad & Nutr, Cordoba, Spain
[11] Tech Univ Munich, Pharmaceut Radiochem, Munich, Germany
[12] Culler Consulting LLC, Hopkinton, MA USA
[13] Cedars Sinai Med Ctr, Dept Med, Pituitary Ctr, Los Angeles, CA 90048 USA
基金
美国国家卫生研究院; 英国医学研究理事会;
关键词
PROTEIN-COUPLED RECEPTORS; MEDULLARY-THYROID CARCINOMA; MESSENGER-RIBONUCLEIC-ACID; GROWTH-HORMONE-RELEASE; PITUITARY-TUMOR CELLS; DISTINCT SIGNALING PATHWAYS; IN-VITRO CHARACTERIZATION; NEOPLASTIC HUMAN TISSUES; PHOSPHOTYROSINE PHOSPHATASE-ACTIVITY; PREOPERATIVE OCTREOTIDE TREATMENT;
D O I
10.1124/pr.117.015388
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Somatostatin, also known as somatotropinrelease inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G protein- coupled receptors (GPCRs) called somatostatin receptor (SST) 1-5. These five receptors share common structural features and signaling mechanisms but differ in their cellular and subcellular localization andmode of regulation. SST2 and SST5 receptors have evolved as primary targets for pharmacological treatment of pituitary adenomas and neuroendocrine tumors. In addition, SST2 is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions. This review article summarizes findings published in the last 25 years on the physiology, pharmacology, and clinical applications related to SSTs. We also discuss potential future developments and propose a new nomenclature.
引用
收藏
页码:763 / 835
页数:73
相关论文
共 50 条
  • [41] International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II-Related Peptide, and Their Receptor: From Structure to Function
    Vaudry, Hubert
    Leprince, Jerome
    Chatenet, David
    Fournier, Alain
    Lambert, David G.
    Le Mevel, Jean-Claude
    Ohlstein, Eliot H.
    Schwertani, Adel
    Tostivint, Herve
    Vaudry, David
    [J]. PHARMACOLOGICAL REVIEWS, 2015, 67 (01) : 214 - 258
  • [42] International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors-Family B G Protein-Coupled Receptors
    Gardella, Thomas J.
    Vilardaga, Jean-Pierre
    [J]. PHARMACOLOGICAL REVIEWS, 2015, 67 (02) : 310 - 337
  • [43] International Union of Pharmacology.: XV.: Subtypes of γ-aminobutyric acidA receptors:: Classification on the basis of subunit structure and receptor function
    Barnard, EA
    Skolnick, P
    Olsen, RW
    Mohler, H
    Sieghart, W
    Biggio, G
    Braestrup, C
    Bateson, AN
    Langer, SZ
    [J]. PHARMACOLOGICAL REVIEWS, 1998, 50 (02) : 291 - 313
  • [44] International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand
    Read, Cai
    Nyimanu, Duuamene
    Williams, Thomas L.
    Huggins, David J.
    Sulentic, Petra
    Macrae, Robyn G. C.
    Yang, Peiran
    Glen, Robert C.
    Maguire, Janet J.
    Davenport, Anthony P.
    [J]. PHARMACOLOGICAL REVIEWS, 2019, 71 (04) : 467 - 502
  • [45] International union of pharmacology.: XXIV.: Current status of the nomenclature and properties of P2X receptors and their subunits
    Khakh, BS
    Burnstock, G
    Kennedy, C
    King, BF
    North, RA
    Séguéla, P
    Voigt, M
    Humphrey, PPA
    [J]. PHARMACOLOGICAL REVIEWS, 2001, 53 (01) : 107 - 118
  • [46] International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)
    Offermanns, Stefan
    Colletti, Steven L.
    Lovenberg, Timothy W.
    Semple, Graeme
    Wise, Alan
    IJzerman, Adriaan P.
    [J]. PHARMACOLOGICAL REVIEWS, 2011, 63 (02) : 269 - 290
  • [47] International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (vol 66, pg 1, 2014)
    Bachelerie, F.
    Ben-Baruch, A.
    Burkhardt, A. M.
    Combadiere, C.
    Farber, J. M.
    Graham, G. J.
    Horuk, R.
    Sparre-Ulrich, A. H.
    Locati, M.
    Luster, A. D.
    Mantovani, A.
    Matsushima, K.
    Murphy, P. M.
    Nibbs, R.
    Nomiyama, H.
    Power, C. A.
    Proudfoot, A. E., I
    Rosenkilde, M. M.
    Rot, A.
    Sozzani, S.
    Thelen, M.
    Yoshie, O.
    Zlotnik, A.
    [J]. PHARMACOLOGICAL REVIEWS, 2014, 66 (02) : 467 - 467
  • [48] International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide
    Harmar, AJ
    Arimura, A
    Gozes, I
    Journot, L
    Laburthe, M
    Pisegna, JR
    Rawlings, SR
    Robberecht, P
    Said, SI
    Sreedharan, SP
    Wank, SA
    Waschek, JA
    [J]. PHARMACOLOGICAL REVIEWS, 1998, 50 (02) : 265 - 270
  • [49] International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases
    Dessauer, Carmen W.
    Watts, Val J.
    Ostrom, Rennolds S.
    Conti, Marco
    Dove, Stefan
    Seifert, Roland
    [J]. PHARMACOLOGICAL REVIEWS, 2017, 69 (02) : 93 - 139
  • [50] International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
    Wu, Long-Jun
    Sweet, Tara-Beth
    Clapham, David E.
    [J]. PHARMACOLOGICAL REVIEWS, 2010, 62 (03) : 381 - 404