Regioselective fluorination in synthesis of deoxyfluoro quercitols from D-(-)-quinic acid

被引：1

作者：

Shih, Tzenge-Lien ^{[1
]}

Liao, Wen-Yu ^{[1
]}

Yen, Wen-Chun ^{[1
]}

机构：

[1] Tamkang Univ, Dept Chem, New Taipei City 25137, Taiwan

来源：

TETRAHEDRON | 2014年 / 70卷 / 51期

关键词：

Deoxyfluoro quercitols; Fluorination; Glycosidase inhibitors; Regioselective fluorination; D-(-)-Quinic acid; ENANTIOSELECTIVE SYNTHESIS; EXPEDITIOUS SYNTHESIS; FACILE SYNTHESIS; ANALOG;

D O I：

10.1016/j.tet.2014.11.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of six new deoxyfluoro querciotls from D-(-)-quinic acid is described. The key steps involve the regioselective fluorination as well as highly stereoselective dihydroxylation. These synthetic deoxyfluoro quercitols are considered as potential glycosidase inhibitors. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：9621 / 9627

页数：7

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