Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk

被引:79
|
作者
Yin, Lu [1 ]
Raum, Elke [1 ]
Haug, Ulrike [1 ]
Arndt, Volker [1 ]
Brenner, Hermann [1 ]
机构
[1] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69115 Heidelberg, Germany
关键词
Serum vitamin D; Prostate cancer; Meta-analysis; RECEPTOR GENE POLYMORPHISMS; SUBSEQUENT DEVELOPMENT; MORTALITY-RATES; D METABOLITES; 25-HYDROXYVITAMIN-D; CALCIUM; 1,25-DIHYDROXYVITAMIN-D; SUNLIGHT; ASSOCIATION;
D O I
10.1016/j.canep.2009.10.014
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: To review and summarize evidence from longitudinal studies on the association between serum 25-hydroxyvitamin D (25(OH)D) and the risk of prostate cancer (PC). Methods: Relevant prospective cohort studies and nested case-control Studies published until July 2009 were identified by systematically searching Ovid Medline, EMBASE, and ISI Web of Knowledge databases and by cross-referencing. The following data were extracted in a standardized manner from eligible studies: first author, publication year, country, study design, characteristics of the study Population, duration of follow-up, PC incidence/PC mortality according to serum vitamin D status and the respective risk ratios, and covariates adjusted for in the analysis. Due to the heterogeneity of studies in categorizing serum vitamin D levels, all results were recalculated for an increase in serum 25(OH)D by 10 ng/ml. Summary odds ratios (ORs) were calculated using meta-analysis methods. Results: Overall, eleven original articles were included, ten of which reported on the association between serum vitamin D levels and PC incidence and one article reported on the association with PC mortality. Meta-analysis of studies on PC incidence resulted in a summary OR (95% confidence interval, CI) of 1.03 (0.96-1.11) associated with an increase of 25(OH)D by 10 ng/ml (P = 0.362). No indication for heterogeneity and publication bias was found. Conclusions: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:435 / 445
页数:11
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